The ρ1 GABAC receptor is a ligand-gated chloride ion channel that shows promise as a therapeutic target for myopia, sleep disorders, memory and learning facilitation, and anxiety-related disorders. As such, there is a need for molecular probes to understand the role GABAC receptors play in physiological and pathological processes. To date, no labeled (either radioactive or fluorescent) GABAC se...

Achieving site selectivity in carbon-hydrogen (C-H) functionalization reactions is a formidable challenge in organic chemistry. Herein, we report a novel approach to activating remote C-H bonds at the C5 position of 8-aminoquinoline through copper-catalyzed sulfonylation under mild conditions. Our strategy shows high conversion efficiency, a broad substrate scope, and good toleration with diffe...

We report the synthesis and biological evaluation of a series of (-)-englerin A analogues obtained along our previously reported synthetic route based on a stereoselective gold(I) cycloaddition process. This synthetic route is a convenient platform to access analogues with broad structural diversity and has led us to the discovery of unprecedented and easier-to-synthesize derivatives with an un...

Ni-doped Mo carbide with Ni/Mo atomic ratio of 0.1 was supported on SiO2, Al2O3, and a porous carbon material (C), using combination gel combustion impregnation methods. XRD, XPS, XANES, EXAFS analyses indicated that the main active sites for catalysts were metallic nickel carbides. The evaluated in furfural hydrogenation to produce 2-methylfuran (2-MF) batch reactor at 150 °C under hydrogen pr...

Cobalt-containing lignin-based fibers were synthesized in one step by electrospinning of Alcell lignin solutions as carbon precursor, a low-cost and renewable co-product the paper making industry. The thermostabilized air to avoid fusion during carbonization process between 500-800 ºC obtain cobalt-containing porous submicron fibers. These catalysts studied for Low-Temperature Fischer-Tropsch s...

C5 palsy is a common complication after cervical decompressive surgery, which have 0 to 30% complication rate. A 61-year-old female patient with cervical spondylotic myelopathy showed bilateral C5 palsy following circumferential decompression and fusion. Unexpectedly, bilateral C5 palsy was noted in different time points on postoperative day 2 and 8, respectively. Steroid injection and physical...

We evaluated the role of complement component C5 during the course of cerebral ischemic reperfusion injury in a rat model of middle cerebral artery occlusion (MCAO). Systemic C5 inhibition was achieved with an anti-C5 monoclonal antibody, which significantly prevented the deterioration of the motor functions by reducing cerebral lesion and edema. Our results show that activated C5 complement co...

Primary or acquired resistance of tumours to established chemotherapeutic regimens is a major concern in oncology. Attempts to improve the survival of cancer patients largely depend on strategies to prevent tumour cell resistance. 5-Fluorouracil (5-FU)-based chemotherapy with a combination of other drugs such as irinotecan (IRT) and oxaliplatin (OXT) has been reported to be effective, even thou...

This article presents the conditions for conversion of hemicellulose with different contents C6 and C5 carbohydrates uronic acids based on OrganoCat process, abbreviations M1, M2, M3 are used. Homogenous catalysis sulfuric acid (VI) in concentration range 0.1–1 M was used study to determine its activity ability transform a mixture. The process carried out using one-pot technique temperature 100...

In this work, multi-promoters, including potassium, manganese and titanium, were incorporated into iron catalyst for improving CO2 hydrogenation the influences of each promoter investigated in detail. Besides, content component was optimized to achieve a well-matching tandem catalysis performance between reverse water gas shift (RWGS) reaction chain propagation reaction. The results showed that...