This paper proposes a semiparametric maximum likelihood estimator for both the intercept and slope parameters in a binary choice model under symmetry and index restrictions. The estimator attains the semiparametric e$ciency bound in Cosslett (1987) under the symmetry and independence restrictions. Compared with the estimator of Klein and Spady (1993), which attains the semiparametric e$ciency b...

BACKGROUND Metabolomic processes have been identified as being strongly linked to the development of Alzheimer's disease (AD). Thus, lipid metabolites appear to be highly useful as diagnostic substrates for the diagnosis of AD and mild cognitive impairment (MCI) in plasma. METHODS We analyzed plasma samples from controls (n = 35), MCI (n = 33), and AD patients (n = 43) using the AbsoluteIDQ p...

Dependence Measures in Bivariate Gamma Frailty Models Bivariate duration data frequently arise in economics, biostatistics and other areas. In “bivariate frailty models”, dependence between the frailties (i.e., unobserved determinants) induces dependence between the durations. Using notions of quadrant dependence, we study restrictions that this imposes on the implied dependence of the duration...

To prove that the peptidic HIV-1 fusion inhibitors containing the pocket-binding domain (PBD) mainly target the hydrophobic pocket in the gp41 N-terminal heptad repeat (NHR), we constructed pseudoviruses by replacement of Q64 in the gp41 pocket region with Ala (Q64A) or Leu (Q64L). These viruses were highly resistant to C34 and CP32M containing the PBD, while they were susceptible to T20 (enfuv...

Then cuIi = 0. Hence every c -̂Ii = 0, Ji = L44. But Ii is free of At. Hence h = Ö, I = 0, £ = 0. THEOREM. Every linear covariant of q± is a linear function ofL,A4L,KL. Next, let co > 1. After subtracting from C a constant multiple of qJJ*", whose leader is b^u, we have d = 0 in S. Express S± as a polynomial in c^, cw, fei, and call p the coefficient of their product. The coefficient of c^Cis in...

Smoking Persistence Across Countries: An Analysis Using Semi-Parametric Dynamic Panel Data Models with Selectivity We study smoking persistence in ten countries using data from the European Community Household Panel. Such persistence may be due to true state dependence but may also reflect individual unobserved heterogeneity. We distinguish between the two by using semiparametric dynamic panel ...

Apratoxins are cytotoxic natural products originally isolated from marine cyanobacteria that act by preventing cotranslational translocation early in the secretory pathway to downregulate receptor levels and inhibit growth factor secretion, leading to potent antiproliferative activity. Through rational design and total synthesis of an apratoxin A/E hybrid, apratoxin S4 (1a), we have previously ...

In this paper, we combine banking and car insurance data to examine the relationship between individual insurance demand and wealth. Controlling for the value of the car, we provide evidence for a positive relationship, suggesting that insurance is a normal good. This result contrasts with the common Decreasing Absolute Risk Aversion (DARA) hypothesis. However, we show that the investment in ri...

serum positive for anti-HIV-I antibody, R-N; reference serum negative for anti-HIV-I antibody, H-(1); healthy control positive for anti-P25 antibody, SY; syphilis patient (S-6) positive for anti-P25 and anti-P55 antibodies, SLE-(1); SLE patient (LA/aCL negative) (N-9) positive for anti-P52 and anti-P68 antibodies, SLE-(2); SLE patient with aCL (C-2), positive for anti-P25 and anti-P52 antibodies].