The authors studied the effect of changes in arterial carbon dioxide tension on plasma tidocaine concentrations dltring a constant lidocaine infusion in eight healthy volunteers. With a PaC02 of 41.4 : 0.9 mmttg (mean • SE). total plasma lido. caine concentrations were 3.97 ~0.20 tzg.ml t. There was no significant change associated with hypercarbia (PaCO 2 = 55~7 • 1.5 mmtfg, lidoeaine = 3.93 •...

In a previous paper (Schaefer et al., 1955) it was reported that incubation in air with increased CO2 content enhances the growth of many strains of tubercle bacilli on oleic acidalbumin agar medium. Two of our stock laboratory strains, Vall6e (bovine) and H37Rv (human), showed diminished growth or even no growth when incubated under a C02-enriched atmosphere on this medium.' Occasionally, howe...

Ab initio calculations of electronic states of the dication C02+, using highly efficient configuration-interattion procedures, are reported. For the lower states, energies are believed to be accurate to within 0.2 eV, but the higher states are less reliable. The complexity of the problem is due to mixing of states of radically different character, such as strongly bound chargepolarization state...

The relation of CO2 to the metabolism of Penicillium chrysogenum has been studied in three ways in this work: (1) attempts were made to replace C02; (2) radioactive C1402 was used to determine the conditions under which CO2 fixation occurred; and (3) attempts were made to identify some of the products of CO2 fixation, especially amino acids. These methods, singly or in combination, have been us...