Background: The electrical dose selected for electroconvulsive therapy (ECT) must have an acceptable efficacy and no or minimal cognitive side-effects. We evaluated the clinical efficacy and cognitive side-effects of ECT in relation to the stimulus dose administered. Method: This study assessed 71 depressed patients who were treated with bilateral ECT. For evaluation of depressive and cognitive...

M e t h o d s Design: Randomized controlled trial (Bypass versus angioplasty in severe ischaemia of the leg [BASIL] trial). Allocation: Unclear allocation concealment.* Blinding: Unblinded.* Follow-up period: 5 years. Setting: 27 hospitals in the United Kingdom. Patients: 452 patients (67% patients ≥ 70 y, 60% men) with severe limb ischemia (defined as rest pain or tissue loss [ulcer or gangren...

M e t h o d s Design: Randomized placebo-controlled trial (Clinical Antipsychotic Trials of Intervention Effectiveness—Alzheimer’s Disease ). Allocation: Concealed.* Blinding: Blinded (clinicians and patients).* Follow-up period: Up to 36 weeks. Setting: 42 sites in the United States. Patients: 421 outpatients (mean age 78 y, 56% women) who had AD or probable AD. All patients had had psychosis,...

Patients: 601 patients (mean age 64 y, 57% men) who were conscious, had a computed tomography–confirmed spontaneous lobar ICH (volume 10 to 100 mL) ≤ 1 cm from the cortical surface of the brain, and presented ≤ 48 hours after ictus. Exclusion criteria included hemorrhage that was intraventricular, due to arteriovenous malformation confirmed by angiography or an aneurysm, secondary to tumor or t...

Background: Successful in vitro maturation (IVM) of oocytes is an important step for production of livestock through assisted reproductive techniques including somatic cell nuclear transfer (SCNT). Obtaining an optimal duration for maturation of oocyte is essential, since over exposure to maturation medium results in oocyte aging, while under exposure leads to production of immature incompetent...

Background: Few studies assessed the association of weight of premature infant and aromatherapy as a secondary outcome. Aim of study was to evaluate all clinical trials on the association of weight of premature infant and aromatherapy. Materials and Methods: All clinical trials evaluating the association of weight of premature infant and...