In 1948, Wolff and Chaikoff reported that organic binding of iodide in the thyroid was decreased when plasma iodide levels were elevated (acute Wolff-Chaikoff effect), and that adaptation or escape from the acute effect occurred in approximately 2 days, in the presence of continued high plasma iodide concentrations. We later demonstrated that the escape is attributable to a decrease in iodide t...

A simple and rapid way to measure the concentration of iodide in urine with an iodide-selective ion electrode was described. Potentiometric equilibrium was attained in less than 5 min, and a linear calibration curve was obtained over the potassium iodide (KI) concentration range of 10(-2) to 10(-6) M. The coefficients of variation ranged from 6.2 to 10.0% within assay, and 5.4 to 14.4% between ...

Measurement of the rate of accumulation of radioiodine by the thyroid gland is of considerable clinical value, since in most instances an avid uptake of radioiodine may be correctly assumed to be due to a high rate of uptake of stable iodide by the thyroid. This measurement, expressed as a percentage of the administered radioiodine dose accumulated per unit time by the thyroid, does not give a ...

We assessed a nonradioactive approach to induce apoptosis in non-small cell lung cancer by a novel iodide uptake and retention mechanism. To enhance tumor apoptosis, we transduced non-small cell lung cancer cells with retroviral vectors containing the sodium iodide symporter (NIS) and thyroperoxidase (TPO) genes. Expression of NIS and TPO facilitated concentration of iodide in tumors. As a cons...

The crystal structure of dl-alanine hydro-iodide (1-carb-oxy-ethanaminium iodide), C(3)H(8)NO(2) (+)·I(-), is that of an organic salt consisting of N-protonated cations and iodide anions. The compound features homochiral helices of N-H⋯O hydrogen-bonded cations in the [010] direction; neighbouring chains are related by crystallographic inversion centers and hence show opposite chirality. The io...

The importance of dietary iodide on the reported hypothyroid effect of drinking water disinfectants on thyroid function was investigated. Previous studies have also showed differences in the relative sensitivity of pigeons and rabbits to chlorinated water. Pigeons and rabbits were exposed for 3 months to diets containing high (950 ppb) or low (300 ppb) levels of iodide and to drinking water con...

Previous studies have suggested that phytoplankton play an important role in the biogeochemical cycling of iodine, due to the appearance of iodide in the euphotic zone. Changes in the speciation of iodine over the course of the growth cycle were examined in culture media for a variety of phytoplankton taxa (diatoms, dinoflagellates and prymnesiophytes). All species tested showed the apparent ab...

To the Editor: We present 2 cases of bilateral swelling of the parotid glands appearing after application of contrast media. This unusual reaction is also known as Biodide mumps.[ As there is no premedication that can prevent its appearance, it is advisable in these cases to use imaging systems without iodide-based contrast media. The first case was a 70-year-old man with significant bilateral,...