F(1) hybrid chicks isogenic for the strong B histocompatibility locus and for most weak H-loci were X-irradiated on day 1 after hatching, injected intraperitoneally on day 2 with dispersed cells of bursa, spleen, or thymus from 4- or 10-wk-old F(1) hybrid donors, and immediately challenged by the same route with either Brucella abortus, sheep erythrocytes, or a mixture of both together. The agg...

B. Glick et all,2 found that the antibody-producing ability is markedly re duced when the bursa of Fabricius (abbreviated as BF) of the newly-hatched chick is removed. Thus the function of this organ which is specific for birds received a great deal of attention. With the comparative study of bursectomy and thymectomy, it has been ascertained that the BF and the thymus play distinctive roles in...

A sudden appearance of a malignant lymphoid tumor, which we characterized as reticulum cell sarcoma, was ob served in a sequestered colony of Auburn strain 571 Japanese quails on the campus of the University of Hawaii, Honolulu. Tumor infiltrations were present in thymuses, spleens, livers, and, less commonly, in the caeca and bursa of Fabricius. In the advanced stages, other organs, such as ki...

The primary feature of vvIBDV is the ability to induce high mortality. Mortality ranges from 5% – 25% in broilers and 30% – 70% in layers. Surviving birds are severely affected with a high condemnation rate. vvIBDV induces clinical signs similar to Gumboro disease, which is induced by classical virulent strains of IBDV, except that the disease is more pronounced and acute in individual birds an...

The immunocompetent cells that can recognize foreign structures by their own actively synthesized antigen-binding receptors are the lymphocytes (1). Two major groups of lymphocytes exist, with separate functions andwithout ability to transform into each other (2, 3) . One group is called T lymphocytes, due to their dependence on the presence of the thymus for development (2). The second group o...

The immunocompetent cells that can recognize foreign structures by their own actively synthesized antigen-binding receptors are the lymphocytes (1). Two major groups of lymphocytes exist, with separate functions andwithout ability to transform into each other (2, 3) . One group is called T lymphocytes, due to their dependence on the presence of the thymus for development (2). The second group o...

Two types of strains of serotype I of infectious bursal disease virus (IBDV) have been described, on the basis of their ability (IBDV-TC) or inability (IBDV-BU) to infect chicken embryonic cells in culture. However, both types infect B lymphocytes in the bursa of Fabricius of young chickens. To determine the molecular basis for tissue culture infectivity, virus recombinants with chimeric segmen...

Previous reports from our laboratory have demonstrated that an reverse phase HPLC (rpHPLC) fraction obtained from extracts of the chicken bursa of Fabricius posses both in vitro anti-steroidogenic activity on avian and mammalian cells and suppression on mitogen stimulated DNA-synthesis in chicken BF cells. Utilizing YM cut-off membranes the bioactive fraction appears to be between ~3-5kDa. Howe...