A stability-indicating liquid chromatography method for the determination of the antifungal agent butenafine hydrochloride (BTF) in a cream was developed and validated using the Plackett-Burman experimental design for robustness evaluation. Also, the drug photodegradation kinetics was determined. The analytical column was operated with acetonitrile, methanol and a solution of triethylamine 0.3%...

Dextran a bacterial exopolysaccharide and a polymer of glucose is produced by different microorganisms like Leuconostoc mesenteroides, Lactobacillus spp, Streptococcus mutans, Weissella confusa etc. It has a wide range of applications in the food, pharmaceutical and other industries. Dextran and its derivatives like iron dextran, clinical dextran, food grade dextran are rapidly emerging as new ...

Response surface methodology was applied to optimize medium constituents for enzymatic production of L-cysteine from DL-2-amino-D-thiazoline-4-carboxylic acid (DL-ATC) by a novel Pseudomonas sp. Zjwp-14. With the Plackett-Burman design experiment, glycerol, DL-ATC, yeast extract, and pH were found to be the most powerful factors among the eight tested variables that influence intracellular enzy...

In attempting to account for the frightful mortality that occurred during the Burman war, it may be necessary to introduce a medico-topographical sketch of the country, and of the peculiar circumstances to which the naval and military forces had been exposed. A comparison, also, of the more violent diseases under which our troops suffered, with those of Hither India, whose more prominent sympto...

will be considered where a and b are taken to be real and pos itive and independent of z. Also, m is a positive integer and Alii is independent of z. When b = a, thi s profile reduces to a symmetric profil e, as previously considered [W ait and Jackson, 1964; Burman, 1965]. When b ¥ a, the profil e is asymmetric . It is found from tables of transform s [e.g., Campbell and Foster, 1948, p. 68] that

This is an "11 factor-2 level-12 run" Plackett-Burman experimental design dataset. The dataset includes 11 engineering bioreactor parameters as input variables. These 11 factors were varied at 2 levels and 23 response variables that are glycan profile attributes, were measured "A Design Space Exploration for Control of Critical Quality Attributes of mAb" (H. Bhatia, E.K. Read, C.D. Agarabi, K.A...