Lymphomas accounts about 10% of all childhood malignancies, and non-Hodjkin's lymphomas are the major group of lymphomas in children, so it's necessary to increase our knowledge about this subject. This descriptive study was performed on 60 cases of non-Hodjkin's lymphoma aged 0-14 years, referring to Mophid Ped. Hospital in seven years (1369-1375). The considered parameters are type, grading,...

Introduction: Primary gastric lymphoma (PGL) is a rare tumor, whose differential diagnosis may become complicated without precise immunohistochemistry (IHC) and genetic analysis. Case Presentation: A 33-year-old woman presented with gastric cancer and had undergone gastrectomy without precise IHC and staging in another center. Inappropriate IHC after surgery showed diffuse large B-cell lymphom...

Burkitt lymphoma is endemic in the Equatorial Belt of Africa, its molecular hallmark is an activated, MYC gene mostly due to a chromosomal translocation. Especially in its endemic clinical variant, Burkitt lymphoma is associated with the oncogenic Epstein-Barr virus (EBV), and holoendemic malaria acts as an amplifier. Environmental factors may also cooperate in Burkitt lymphomagenesis in the en...

The optimal use of transcription factors to determine B-lineage specificity in B-acute lymphoblastic leukemia/lymphoma (B-ALL) has not been fully investigated. We undertook an extensive immunohistochemical study of a panel of B-cell transcription factors in B- and T-ALL and Burkitt lymphoma to evaluate those with the best specificity and sensitivity. Tissue microarrays were constructed from 34 ...

Non-Hodgkin lymphomas (NHLs) are increasing in incidence and will be diagnosed in more than 55,000 individuals this year alone [1,2]. The 13 most frequent clinical classes recognized in the lymphoma classification include diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), small lymphocytic lymphoma (SLL) mantle cell lymphoma (MCL), peripheral T-cell lymphoma (PTCL), marginal B-cel...

Burkitt's lymphoma is a highly aggressive lymphoma identified and described in the last century by Denis Burkitt in Africa, in areas endemic for malaria. Since its description in African children, it has been recognized outside areas with endemic malaria, frequently also in children as well as among individuals with an underlying immunodeficiency. Since its initial designation as Burkitt's lymp...

data are lacking. The published series treated with hyper-CVAD rituximab appear to relate to a heterogeneous group of patients of which only one-third had a MYC rearrangement.5 Using the current edition of the WHO classification, it is likely that most of the cases in the Manchester series would be placed in the category “B-cell lymphoma, unclassifiable, with features intermediate between diffu...