Burkitt lymphoma is a fast-growing Non-Hodgkin's Lymphoma that originates from mature B cells. It is generally associated with chromosomal translocations or/and Epstein– Barr virus infection leading to deregulated activation of the c-myc oncogene. Combination chemotherapy with a vincristine-containing regimen is the treatment of choice in Burkitt lymphoma, however, only 50% of the patients resp...

In an earlier report (G. Henle and W. Henle, J. Bacteriol. 91:1248, 1966), results of immunofluorescence tests with cultured cells from Burkitt lymphomas were described, and evidence was presented that the small proportion of stainable cells might be those which harbor as yet unidentified herpeslike virus particles (M. A. Epstein et al., Wistar Inst. Symp. Monograph 4:69, 1965; S. E. Stewart et...

The benefit of intrathecal therapy and systemic rituximab on the outcome of diffuse large B-cell lymphoma at risk of central nervous system disease is controversial. Furthermore, the effect of intrathecal treatment and rituximab in diffuse large B-cell and Burkitt lymphoma with occult leptomeningeal disease detected by flow cytometry at diagnosis is unknown. Untreated diffuse large B-cell (n=24...

Resumen El linfoma de Burkitt es un no Hodgkin células B, que representa el 4% la patología tumoral. Existen tres formas clínicas, siendo esporádica más frecuente en nuestro medio, sobre todo niños o adultos jóvenes. Describimos caso pancreático y ovárico, clínica debut ictericia asintomática lo determina inicio del estudio. Como resultados conclusión, destacar una entidad poco i...

The majority of chromosomal rearrangements observed in Burkitt lymphomas involve a translocation between 8q and 14q, while the remaining minority carry variant translocations between chromosome 8 and either 2 or 22. We have studied the JI Burkitt lymphoma cell line carrying the variant 2;8 chromosome translocation using a combination of high-resolution and molecular cytogenetic techniques. We h...