Acidic pKas of histidines buried within the protein interior are frequently rationalized on the contradictory basis of either polar interactions within the protein or the effects of a hydrophobic environment. To examine these relationships, we surveyed the buried surface area, depth of burial, polar interactions, and crystallographic temperature factors of histidines of known pKa. It has been f...

We describe plasmon propagation in silica-filled coupled nanovoids fully buried in gold. Propagation bands and band gaps are shown to be tunable through the degree of overlap and plasmon hybridization between contiguous voids. The effect of disorder and fabrication imperfections is thoroughly investigated. Our work explores a novel paradigm for plasmon photonics relying on plasmon modes in meta...

It's a truism that structures are helpful for mechanistic understanding of protein function, and nowhere is this dictum better illustrated than with ClC-type Cl Ϫ channels , a large molecular family found in virtually every type of cell in every biological niche. These channels, first observed over 20 yr ago (White and Miller, 1979; Miller, 1982), are now known from a barrage of knockout studie...

THIS is a preliminary report of a new magnetic ocular obturator for use after enucleation of the globe. It is a completely buried implant. An attempt has been made to bring the research, design, construction, and surgery of the new instrument into continuity with previous models of the post-eviscerative type, some partially buried and some wholly buried within the orbital structure, applying th...

In this paper, we propose a method for extraction of signals correlated with noise in which they are buried. The proposed extraction method uses no a-priori information on the buried signal and works independently of the nature of noise, correlated or not with the signal, colored or white, Gaussian or not, and locations of its spectral extent. Extraction of buried correlated signals is achieved...

The progressive shear failure of a rock mass under hydromechanical coupling is key aspect the long-term stability deeply buried, high fluid pressure diversion tunnels. In this study, we use experimental and numerical analysis to quantify permeability variations that occur in an intact marble sample as it evolves from slip different confining pressures pressures. results reveal at low effective ...

BACKGROUND AND STUDY AIMS  Buried bumper syndrome is an infrequent complication of percutaneous endoscopic gastrostomy (PEG) that can result in tube dysfunction, gastric perforation, bleeding, peritonitis or death. The aim of this study was to compare the efficacy of different PEG tube removal methods in the management of buried bumper syndrome in a large retrospective cohort. PATIENTS AND ME...

The study of palaeo-glacial landforms and sediments can give insights into the nature dynamics ice sheets. This is particularly case with regards to subglacial record, which challenging observe in contemporary glaciated settings hence remains only partially understood. hydrological system an essential component dynamics, where increased water pressure enhances motion sediment deformation, thus ...