background the dilution and rapid elimination of topically applied drugs due to the flushing action of saliva is a major difficulty in the effort to eradicate infections of oral cavity. utilization a proper delivery system for incorporation of drugs has a major impact on drug delivery and such a system should be formulated for prolonged drug retention in oral cavity. objectives the aim of the p...

Buprenorphine and buprenorphine-naloxone fixed combinations are effective for managing patients with opioid dependence, but constipation is one of the most common side effects. Evidence indicates that the rate of constipation is lower when patients are switched from sublingual buprenorphine-naloxone tablets or films to a bilayered bioerodible mucoadhesive buccal film formulation, and while the ...

giant cell fibroma (gcf) was described as a new entity of fibrous hyperplastic soft tissue. it seems that stimulus from an unexplained origin can have a role in its etiology. histopathologically gcf is consisted of multinucleated fibroblasts that have oval shape nuclei within the eosinophilic cytoplasm. surgical excision is the treatment of choice and recurrence is very rare. here we report a c...

There is a high unmet medical need for child-appropriate oral dosage forms. The acceptability of novel placebo orally dispersible tablet formulation (pODT) was therefore evaluated. Monolithic tablets contain an inorganic calcium carbonate/calcium phosphate carrier material as the main excipient. They were assessed in cross-sectional study. 40 child participants between 2 to 5 years and 6 10 old...

aluminum phosphide (alp) as 3 g tablet is widely used in iran to protect stored food grains from pests. hyperglycemia following its ingestion has been already reported in the recent years but severe hypoglycemia is uncommon. here, we report a 19 year old male who attempted suicide with one tablet of alp and demonstrated severe hypoglycemia. despite restoration of blood glucose concentration to ...

Clonazepam (CLZ), an antipsychotic drug reported for its efficiency in managing anxiety-related disorders, is being marketed only as conventional tablets. Some patients have abstention to swallow the tablets; therefore, proposed study was aimed at developing a buccal lozenge tablet by direct compression of two types optimized granules. Conazepam’s water solubility first enhanced solid dispersio...

*Corresponding author: Amit Gupta School of Pharmacy and Technology Management SVKM’s NMIMS Deemed University Mumbai400056 Maharastra, India Telephone number: +91-2264521148/49/50 Fax: +91 22 26185422 E-mail: [email protected] [email protected] [email protected] Abstract: Extended release Buccoadhesive buccal tablet for delivery of Nisoldipine were developed using Progressive hydration ...

propranolol, a prototypical b-adrenergic receptor antagonist and atenolol, a cardio-selective b-antagonist are widely used in therapeutic regimens for treatment of hypertensive patients. in iran, several pharmaceutical manufacturers formulate these two b-blockers. as the formulation of a dosage form is essential for the patient's safety and drug efficacy, in this study we aimed to evaluate...