نتایج جستجو برای: btk expression

تعداد نتایج: 873168  

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2000
A B Satterthwaite F Willis P Kanchanastit D Fruman L C Cantley C D Helgason R K Humphries C A Lowell M Simon M Leitges A Tarakhovsky T F Tedder R Lesche H Wu O N Witte

Modifier screens have been powerful genetic tools to define signaling pathways in lower organisms. The identification of modifier loci in mice has begun to allow a similar dissection of mammalian signaling pathways. Transgenic mice (Btk(lo)) expressing 25% of endogenous levels of Bruton's tyrosine kinase (Btk) have B cell functional responses between those of wild-type and Btk(-/-) mice. We ask...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1997
T Yasue H Nishizumi S Aizawa T Yamamoto K Miyake C Mizoguchi S Uehara Y Kikuchi K Takatsu

CD38 ligation on mouse B cells by CS/2, an anti-mouse CD38 mAb, induced proliferation, interleukin 5 (IL-5) receptor alpha chain expression, and tyrosine phosphorylation of Bruton tyrosine kinase (Btk) from wild-type, but not from X chromosome-linked, immunodeficient mice. B cells from fyn-deficient (Fyn-/-) and lyn-deficient (Lyn-/-) mice showed an impaired response to mAb CS/2 for proliferati...

Journal: :JAMA oncology 2015
Marla D Lipsyc Rona Yaeger Lynn T Dengel Leonard Saltz

inhibition of BTK downregulates expression of myriad downstream signaling molecules, most prominently PLCγ2, some mutations in which seem to mediate ibrutinib resistance. Interestingly, a clinically similar eruption—a lymphohistiocytic infiltrate with eosinophils responsive to corticosteroids—has been described in patients with mutations in the PLCγ2 gene.6 In conclusion, treatment of lymphoid ...

2013
Karin Strijbis Fikadu G. Tafesse Gregory D. Fairn Martin D. Witte Stephanie K. Dougan Nicki Watson Eric Spooner Alexandre Esteban Valmik K. Vyas Gerald R. Fink Sergio Grinstein Hidde L. Ploegh

Phagocytosis of the opportunistic fungal pathogen Candida albicans by cells of the innate immune system is vital to prevent infection. Dectin-1 is the major phagocytic receptor involved in anti-fungal immunity. We identify two new interacting proteins of Dectin-1 in macrophages, Bruton's Tyrosine Kinase (BTK) and Vav1. BTK and Vav1 are recruited to phagocytic cups containing C. albicans yeasts ...

2013
Afitap Derya Köprülü Renate Kastner Sebastian Wienerroither Caroline Lassnig Eva Maria Putz Olivia Majer Benjamin Reutterer Veronika Sexl Karl Kuchler Mathias Müller Thomas Decker Wilfried Ellmeier

In this study we investigated the role of Bruton's tyrosine kinase (Btk) in the immune response to the Gram-positive intracellular bacterium Listeria monocytogenes (Lm). In response to Lm infection, Btk was activated in bone marrow-derived macrophages (BMMs) and Btk (-/-) BMMs showed enhanced TNF-α, IL-6 and IL-12p40 secretion, while type I interferons were produced at levels similar to wild-ty...

Journal: :The Journal of biological chemistry 2003
Caroline A Jefferies Sarah Doyle Cornelia Brunner Aisling Dunne Elizabeth Brint Claudia Wietek Eva Walch Thomas Wirth Luke A J O'Neill

In this study we have identified members of the Toll-like receptor (TLR) family (namely, TLRs 4, 6, 8, and 9) as proteins to which the intracellular protein tyrosine kinase, Bruton's tyrosine kinase (Btk), binds. Detailed analysis of the interaction between Btk and TLR8 demonstrates that the presence of both Box 2 and 3 motifs in the Toll/interleukin-1 receptor domain was required for the inter...

2003
Giles O. C. Cory Ruth C. Lovering Steve Hinshelwood Lucy MacCarthy-Morrogh Roland J. Levinsky Christine Kinnon

X-linked agammaglobulinemia, a B cell immunodeficiency, is caused by mutations in the Bruton's tyrosine kinase (Btk) gene. The absence of a functional Btk protein leads to a failure of B cell differentiation and antibody production. B cell receptor stimulation leads to the phosphorylation of the Btk protein and it is, therefore, likely that Btk is involved in B cell receptor signaling. As a non...

Journal: :The Journal of Experimental Medicine 1995
G O Cory R C Lovering S Hinshelwood L MacCarthy-Morrogh R J Levinsky C Kinnon

X-linked agammaglobulinemia, a B cell immunodeficiency, is caused by mutations in the Bruton's tyrosine kinase (Btk) gene. The absence of a functional Btk protein leads to a failure of B cell differentiation and antibody production. B cell receptor stimulation leads to the phosphorylation of the Btk protein and it is, therefore, likely that Btk is involved in B cell receptor signaling. As a non...

2017
Anne B. Satterthwaite

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the loss of adaptive immune tolerance to nucleic acid-containing antigens. The resulting autoantibodies form immune complexes that promote inflammation and tissue damage. Defining the signals that drive pathogenic autoantibody production is an important step in the development of more targeted therapeutic approaches fo...

Journal: :Journal of immunology 2013
Jennifer C Byrne Joan Ní Gabhann Kevin B Stacey Barbara M Coffey Eoghan McCarthy Warren Thomas Caroline A Jefferies

In addition to regulating B cell development and activation, Bruton's tyrosine kinase (Btk) functions downstream of multiple TLRs, including TLR7, to regulate innate immune responses in myeloid cells. Although critical for defense against RNA viruses such as influenza and Sendai virus, recognition of self-RNA by TLR7 also has been shown to be an important contributor to the pathophysiology of s...

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