Abstract Healthcare organizations and Health Monitoring Systems generate large volumes of complex data, which offer the opportunity for innovative investigations in medical decision making. In this paper, we propose a beetle swarm optimization adaptive neuro-fuzzy inference system (BSO-ANFIS) model heart disease multi-disease diagnosis. The main components our analytics pipeline are modified cr...

In this paper we describe the structure and development of the Brandeis Semantic Ontology (BSO), a large generative lexicon ontology and lexical database. The BSO has been designed to allow for more widespread access to Generative Lexicon-based lexical resources and help researchers in a variety of computational tasks. The specification of the type system used in the BSO largely follows that pr...

The combmed use of the photoelectnc and electro-optic properttes of the BI,,SIO~~ (BSO)-crystal leads to a new posslblhty of reahzmg a spa&xl hght modulator Under certam geometrical condrtions, whxh will be discussed, It 1s possible to reahze, that the BSO-crystal becomes blrefrmgent depending on the local fiummance, the physxal connection between the dlstnbutlons of blrefrmgence and lllummance...

Oxidative stress is thought to play an important role in the pathogenesis of Parkinson's disease (PD). Glutathione (GSH), a major cellular antioxidant, is decreased in the substantia nigra pars compacta of PD patients. The aim of the present study was to investigate whether deprenyl and its desmethyl metabolite, putative neuroprotective agents in the treatment of PD, could protect cultured rat ...

Photodynamic therapy (PDT) is an increasingly popular anticancer treatment that uses photosensitizer, light and tissue oxygen to generate cytotoxic reactive oxygen species (ROS) within illuminated cells. Acting to counteract ROS-mediated damage are various cellular antioxidant pathways. In this study, we combined PDT with specific antioxidant inhibitors to potentiate PDT cytotoxicity in MCF-7 c...

Oxidative stress and endoplasmic reticulum (ER) stress have been implicated in cardiovascular diseases although the interplay between the two is not clear. This study was designed to examine the influence of oxidative stress through glutathione depletion on myocardial ER stress and contractile function in the absence or presence of the heavy metal scavenger antioxidant metallothionein (MT). FVB...

BACKGROUND & AIMS Acquisition of anoikis resistance is a prerequisite for metastasis in hepatocellular carcinoma (HCC). However, little is known about how energy metabolism and antioxidant systems are altered in anoikis-resistant (AR) HCC cells. We evaluated anti-tumor effects of a combination treatment of 3-bromopyruvate (3-BP) and buthionine sulfoximine (BSO) in AR HCC cells. METHODS We com...

BACKGROUND AND OBJECTIVES To review the success and morbidity of laparoscopic major gynecologic surgery in patients with prior laparotomy bowel resection. METHODS Review of a prospective surgical database of all cases of laparoscopic major gynecologic surgery in patients with prior laparotomy bowel resection. No cases were excluded. Bowel diagnoses and procedures were total colectomy for inf...