Adenosquamous lung carcinoma (AdSqLC) has a worse prognosis than adenocarcinoma (ADC) or squamous cell carcinoma (SQCC). Micropapillary pattern in lung ADC is an additional poor prognostic factor. We describe a rare case of AdSqLC with epidermal growth factor receptor (EGFR) mutation in both the micropapillary-ADC and SQCC components, showing long-term response to gefitinib. A 60-year-old woman...

A case-control study was undertaken to study lung cancer in relation to dietary habits, occupational exposure, and living in urban or country areas. Suspect lung cancer cases in West Sweden and population controls were interviewed using a food frequency questionnaire. The study comprised 177 female and 359 male cases and 916 controls. The cases mainly comprised former and current smokers (82% f...

adenocarcinomas. Adenosquamous carcinomas with consisting of both glandular and squamous histologic components are a rare malignancy of the colon and rectum. This tumor type was originally described by Herheimer in 1907. Subsequent reports of adenosquamous carcinomas of the rectum and/or colon are limited as the estimated incidence of adenosquamous carcinomas of the colon and rectum is approxim...

The multicentric origin of certain neoplasms such as those of the stomach, intestines, skin, female genitalia, and pharynx have been well documented.1’2 Until recently, this phenomenon has not been emphasized for carcinoma of the lung except in those examples designated as alveolar cell carcinoma. Excluding the latter, there have been 26 documented cases of multiple primary invasive carcinoma o...

BACKGROUND Adenosquamous carcinoma is an uncommon cutaneous malignant neoplasm with mixed glandular and squamous differentiation and a propensity for aggressive clinical behavior. OBSERVATIONS Of 27 patients diagnosed as having adenosquamous carcinoma, 19 were men and 5 were immunosuppressed. The mean age was 74 years. The majority of tumors were located on the face and scalp (19 of 27 [70%])...

A case of spontaneous pneumothorax complicating irradiation for bronchogenic carcinoma is presented. Pneumothorax developed in a collapsed lung caused by a central bronchogenic carcinoma. The cause is presumably secondary to either a bronchopleural fistula by tumour or sudden expansion of the lung following irradiation. Various tumours of the lung have been associated with spontaneous pneumotho...

This study evaluates local pulmonary immune effector cell lytic activity. Purified lymphocyte populations were isolated from BALF obtained from 18 patients with bronchogenic carcinoma, six patients with lung disorders other than cancer, and ten normal control volunteers matched for age and smoking history. These cells were evaluated for NK and LAK cell lytic activity against NK-resistant LAK-se...

Normal bronchial epithelial cells (NBECs) are at risk for damage from inhaled and endogenous oxidative species and from epoxide metabolites of inhaled polycyclic aromatic hydrocarbons. Epidemiological and in vitro data suggest that interindividual variation in this risk may result from variation in NBEC expression of enzymes that inactivate reactive species by conjugating them to glutathione. Q...

study due to chronic anemia. The microscopical study exhibited a malignant tumor composed of two different epithelial cell types (Fig. 1), with an infiltrating growth pattern, and wide necrotic and hemorrhage areas. Nearly 60% of the tumor was an atypical polygonal cell proliferation with intercellular bridges, keratin, and presence of pearl corns (Fig. 2), which was a squamous carcinoma. The r...

Primary adenosquamous carcinoma of the liver is a very rare type of cholangiocarcinoma and is defined as a cancer containing both squamous and adenomatous components in the same lesion. Recently, we experienced a primary adenosquamous carcinoma of the liver presented as liver abscess. A 63-year-old man was presented with a 4-day history of fever and chill. The radiologic study showed a 4 cm-siz...