BACKGROUND Bronchial epithelial ciliary dysfunction is an important feature of asthma. We sought to determine the role in asthma of neutrophilic inflammation and nicotinamide adenine dinucleotide phosphate (NADPH) oxidases in ciliary dysfunction. METHODS Bronchial epithelial ciliary function was assessed by using video microscopy in fresh ex vivo epithelial strips from patients with asthma st...

RATIONALE AND OBJECTIVES The authors performed this study to determine if bronchial wall thickening is present in children with moderate to severe asthma during periods free from clinical bronchoconstriction. MATERIALS AND METHODS The authors obtained low (radiation) dose thin-section computed tomographic (CT) scans in each of 18 control subjects and 21 children with moderately severe but sta...

We report a patient with chronic bronchiectasis who developed systemic vasculitis. The patient was initially treated with immunosuppression; however, the addition of antibiotic therapy improved control of her vasculitis and the need for immunosuppression was reduced. Chronic bronchial suppuration may have an aetiological role in the pathogenesis of this condition.

Background The concept of Atopic march was developed to study the progress of Atopic Dermatitis to Allergic Rhinitis to Asthma. Epidemiologic studies have constantly demonstrated strong associations between Rhinitis and Asthma. Bronchial hyper-reactivity is an important component in the definition of Asthma. Many patients with Allergic Rhinitis have lower Airway hyperreactivity or bronchial hyp...

INTRODUCTION Bronchial Asthma is one of the most extensively studied respiratory diseases and its genetic basis is well established. Dermatoglyphic traits are formed under genetic control early in development but may be affected by environmental factors during first trimester of pregnancy. These patterns may represent the genetic makeup of an individual and therefore his/her predisposition to c...

Several studies on the prognosis of occupational asthma have shown that a significant proportion of patients continue to experience asthmatic symptoms and nonspecific bronchial hyperresponsiveness after cessation of work. The determinants of this unfavourable prognosis of asthma are: long duration of exposure before the onset of asthma; long duration of symptoms before diagnosis; baseline airwa...

Introduction: Palmar dermatoglyphics is a simple, inexpensive andnon-invasive anatomical procedure which may be used as a reliable indicator for screening of high risk population in a developing country like India. Bronchial asthma is influenced by genetic factors and the present study was carried out to correlate the dermatoglyphic quantitative & qualitative parameters in patients of bronchial...

A double-blind crossover study of the effects of real and placebo acupuncture on bronchial reactivity to histamine was carried out on 16 patients with moderately severe asthma. Treatment with real or placebo acupuncture failed to modulate the bronchial hyperreactivity to histamine. These results suggest that a single treatment with acupuncture is unlikely to provide improvement in the managemen...

The purpose of this investigation was to study factors of importance for the degree of bronchial responsiveness and, furthermore, to evaluate the sensitivity, specificity and predictive value of a bronchial challenge test with histamine for the diagnosis of asthma in 495 randomly selected children and adolescents, aged 7-16 yrs, from Copenhagen, Rigshospitalet. Detailed history about allergic s...

Background: The relationship between fi broblasts, myofi broblasts, and smooth muscle cells within the airway wall remains poorly understood. Objective: The cellular characteristics of primary bronchial fi broblasts from patients with asthma were investigated by evaluating the expression of 3 proteins: α–smooth muscle actin (SMA), fi bronectin containing extra type III domain A (EDAcFN), and sm...