The brine shrimp (Artemia salina Leach) lethality bioassay offers an advantage in standardization and quality control of botanical products. This test is well correlated with antitumor activity (cytotoxicity) and can be used to monitor the activity of bioactive natural products. This paper reports the bioactivity of ethanol extracts from seven medicinal plants from the Northeast of Brazil (Acme...

Three compounds H-1 ($-sitosteryl-$-D glucoside), H-2 (22, 23-dihydro-"-spinosteryl glucoside) & CH-2 (salicylic acid) isolated from the chloroform extract of stem of Ipomoea turpethum and the crude petroleum ether, chloroform and ethyl acetate extracts were screened against thirteen pathogenic bacteria for their antibacterial activities. The minimum inhibitory concentration (MIC) of the isolat...

This atudy was designed to evaluate the antifungal and cytotoxic activities of the Nannorrhops ritchiana (Mazari Palm) 80% methanol extract (NR-M) and its four crude extracts i.e., petroleum ether (NR-A), dichloromethane (NR-B), ethyl acetate (NR-C) and butanol (NR-D). The antifungal activity was determined by agar tube dilution method against nine fungal strains; Aspergillus flavus, Trichophyt...

A newly synthesized Nickel (II) tyrosine complex was screened as potential antimicrobial agent against a number of medically important bacteria (Bacillus subtilis, Streptococcus β-haemolytica, Escherichia coli, Shigella dysenterae) and fungi (Aspergillus fumigatus, Candida albicans, Aspergillus niger, Aspergillus flavus, Penicillium sp.) strains. were used for antifungal activity. The antimicro...

In recent years, great interest has been focused on gold(III) complexes as cytotoxic and antitumor drugs. Recent studies demonstrated that simple bidentate or polydentate ligands containing nitrogen donor atoms may offer sufficient redox stabilization to produce viable Au(III) anticancer drug targets under physiologic conditions. So, we have synthesized square planer Au(III) complexes of type [...

This study was undertaken to evaluate the protective efficacy of the antioxidants vitamin E and Trolox (a water-soluble vitamin E derivative) against the toxicity of microcystin-LR (MC-LR), Microcystis aeruginosa aqueous extract (CE), and a reference toxin, menadione sodium bisulfite (MSB), in Artemia franciscana nauplii. This was achieved by using the well-established brine shrimp bioassay. Th...

Medicinal plants constitute an important component of flora and are widely distributed in India. The pharmacological evaluation of substances from plants is an established method for the identification of lead compounds which can leads to the development of novel and safe medicinal agents. Based on the ethnopharmacological literature, several species of medicinal plants used in traditional medi...

Forty-five fungal isolates from moldy supermarket foods were tested for toxicity to brine shrimp, and twenty-two of these isolates were subsequently tested for toxicity to chicken embryos. Highly toxigenic fungi were Cladosporium sphaerospermum from a bakery product, Fusarium oxysporum from carrots, F. solani from cabbage, Aspergillus niger and Penicillium corylophilum from bread, P. cyclopium ...

A series of mono-, di- and triorganotin compounds with general formulae [RSnL(2)Cl], R = Bu (compound 3), [R(2)SnL(2)], where R = Me, Et, Bu, Oct (compounds 1, 2, 4 and 6) and [R(3)SnL], where R = Bu, Cy and Ph (compounds 5, 7 and 8) and where L = 3,4-methylenedioxy-6-nitrophenylpropenoic acid have been prepared and characterized by elemental analysis, multinuclear ((1)H-, (13)C- and (119)Sn-) ...

In the study of bioactive substances in Illicium plants, the methanol extract of I. merrillianum showed brine shrimp lethality test (BST) activity at 200 microg/ml. Bioassay-guided fractionation of the BST active fractions resulted in the isolation of 4-O-methyleudesm-11-en-4alpha-ol, eudesmol-11-en-4alpha-ol and (-)-hinokinin as potent BST active compounds. On the other hand, four new highly o...