Introduction: In this study, two constituents of saffron stigma (crocin and safranal) were tested for possible cytotoxic and antitumoral activity using brine shrimp and potato disc assays. Methods: In the brine shrimp assay, three wells containing 10 nauplii were tested for each concentration. After 24h, the number of the nauplii was counted. To investigate the antimicrobial activity of safr...

Phytochemical and biological screening of root of Asparagus racemosus was studied. The brine shrimp bioassay of its various extracts showed that the methanol (MeOH) extract was biologically active. The column chromatography of hexane, acetone and methanol extracts resulted in the isolation of 9hexadecanoic acid-9-octadecenylester (Z,Z), β-Sitosterol, stigmasterol-3-O-β-D-glucopyranoside and dio...

The extracellular haemoglobins (Mr 260 000) of the brine shrimp Artemia sp. were cleaved by limited digestion with subtilisin. Structural units of Mr 16 000, which can bind dioxygen reversibly, were isolated. Analysis of the 16 000-Mr fraction (E) reveals the presence of a limited number of structural units. A single type of structural unit, E1 (Mr 15 800; pI4.8), was purified to homogeneity an...

This study reports the synthesis and antioxidant activity of some new acetamide derivatives. The compounds' structures were elucidated by NMR analysis and their melting points were measured. The in vitro antioxidant activity of these compounds was tested by evaluating the amount of scavenged ABTS radical and estimating ROS and NO production in tBOH- or LPS-stimulated J774.A1 macrophages. All co...

Avermectin inhibits Mucor miehei and Artemia salina chitin synthesis and to a degree DNA synthesis in the former. The antibiotic interferes with chitin turnover in brine shrimp and inhibits Streptomyces antibioticus chitinase activity in vitro. In light of the proposed mode of action of avermectin and the anomolies in the literature, it is proposed that avermectin can kill susceptible organisms...

The facile preparation of a racemic hydrazine bridged diphosphonium compound possessing a ring system analogous to bicyclo[3.3.2]decane is reported. Although the reaction yield is low, the structure of the compound, which possesses an eight-membered ring, two phosphonium cationic centers, a biimino bridge, molecular chirality and two fused aromatic rings locked into roughly perpendicular planes...

The marine ascidian Clavelina cylindrica produces a series of interesting tricyclic quinolizidine and indolizidine alkaloids that show toxicity in a brine shrimp assay.1 Cylindricines A (1), C (2), D (3), E (4), and F (5) differ only in the functionality of the methylene substituent in the fivemembered ring. Interestingly, cylindricines A and B (7) interconvert simply upon standing in solution,...

in the present work, the bioassay screening of the essential oil and various extracts of two plants including fruits of heracleum persicum desf. and rhizomes of zingiber officinale rosc. have been studied with brine shrimp test. there is only one report about cytotoxicity of h. sphondylium in literature and so h. persicum has been used as second selection. at first essentials oil and various ex...