Six statistics are compared in a simulation study for their ability to identify geographical areas with a known excess incidence of a rare disease. The statistics are the standardized incidence ratio, the empirical Bayes method of Clayton and Kaldor, Poisson probability, a statistic based on the 'Breslow T' test (BT) and two statistics based on the 'Potthoff-Whittinghill' test (PW) for extra-Po...

in this paper, drift change point estimation in the mean of polynomial profiles is considered. for this purpose, the proposed change point estimator is computed using maximum likelihood approach. performance of the proposed estimator is evaluated using monte carlo simulations when t2 control chart issues an out-of-control signal. simulation results show that the performance of the proposed esti...

this paper presents a discrete-time robust control for electrically driven robot manipulators in the task space. a novel discrete-time model-free control law is proposed by employing an adaptive fuzzy estimator for the compensation of the uncertainty including model uncertainty, external disturbances and discretization error. parameters of the fuzzy estimator are adapted to minimize the estimat...

BACKGROUND/AIM Skin melanoma is one of the most malignant diseases with increasing incidence rate. Sentinel node biopsy (SNB) is very important for early detection of metastatic spread. The aim of the study was to analyze the first 40 patients with skin melanoma of 1 to 4 mm Breslow thickness when SNB was indicated. METHODS The patient characteristics, localization of the primary melanoma as ...

Semiparametric maximum likelihood estimators have recently been proposed for a class of two-phase, outcome dependent sampling models; e.g. Breslow and Holubkov (1997), Scott and Wild (1998), and Lawless, Wild, and Kalb eisch (1999). The estimators studied by these authors are predicated on the estimates of the underlying covariate distribution being concentrated on the observed covariate values...

Introduction Examples of cohort studies in the sexual health literature are now increasingly common. The purpose of this article is to provide an overview of the design and analysis of cohort studies, along with a discussion of some of the potential problems with these studies which may be particularly relevant for cohorts which study factors related to sexual health. A comprehensive guide to t...

Dermoscopy is valid, noninvasive technique for the visualization of different morphological structures within pigmented melanocytic skin lesion. In clinical practice, positive personal history is considered to be as an indication of increased melanoma risk. The thickness of melanoma (Breslow Index) is the most important independent predicting factor of survival for stage I patients. We aimed to...