Breast cancer, as a heterogeneous disease, includes a wide range of pathological and clinical behaviors. Current treatment protocols, including radiotherapy, chemotherapy, and hormone replacement therapy, are mainly associated with poor response and high rate of recurrence. Therefore, more efforts are needed to develop alternative therapies for this type of cancer. Immunotherapy, as a novel str...

results based on the recent researches, certain mmps play critical role in breast cancer initiation, invasion, and metastasis. they can be regarded as predictive biomarkers of primary diagnosis and prognosis of breast cancer and have predictive value for evaluation of disease, tumor recurrence, invading of tumor cells to other sites and therapeutic outcomes. conclusions in summary, the results ...

Tuberculosis (TB) of the breast is a rare disease that typically affects women reproductive age, mainly between 15 and 25 years age. TB has non-specific clinical presentation may present as lump, abscess, or sinus, it sometimes mimic cancer. Histological diagnosis necessary to avoid mismanagement potentially curable disease. We case an 18-year-old female with left upper quadrant lump 1-year dur...

Background and aims: The mortality rate for breast cancer is directly related to the stage of disease at diagnosis. The present study was aimed to determine the factors influencing on knowledge, attitudes, and practices in women with breast cancer and its screening methods. Methods: In a cross- sectional study, we evaluated 383 women who referred to healt...

The disease that involves abnormal cell growth and spreads through the surrounding tissues damaging other parts of body is cancer. Breast cancer most common one out many types. Women are affected by breast either hormonal changes or genetic occur in DNA. As a life-threatening disease, it necessary for further studies to gear up fighting deadliest disease. In this work, detailed study made on oc...

background: in recent years, epidemiologic and laboratory studies have implied that vitamin d deficiency has a role in the pathogenesis of breast cancer. it has shown that vitamin d can prevent tumor progression induced by carcinogens and inhibit the carcinogenic effects of high fat diet on breast tissue and growth of tumor cells. this study aimed to evaluate serum 25-hydroxyvitamin d level and...

background : biomarkers accepted for clinical use in breast cancer have low sensitivity and specificity. thus, there is a need for new markers to assist in the diagnosis, prognosis and follow-up of breast cancer patients. this study aims to investigate the diagnostic, prognostic and follow-up role of serum bcl-2, bax and p53 proteins in breast cancer patients in comparison with those of serum c...

second to the cardiovascular disease, cancer is the main cause of death in iran. in this study some of the risk factors of breast cancer; especially the ones related to breastfeeding have been assessed. the study was a retrospective study of 100 women with breast cancer. the most important risk factors in breast cancer were number of children, age of mother on the first pregnancy. the result sh...