Background and Aim: Basal cell carcinoma (BCC) is considered to be the most common malignancy in humans and occurs primarily in the skin especially in the head and neck region. Considering the high recurrence rate of the tumor, finding a marker for prediction of recurrence is very important. Cancer stem cells are a small subpopulation in the tumors that are related to tumorigenesis and recurren...

Primary and secondary malignant central nervous system (CNS) tumors are devastating invasive tumors able to give rise to many kinds of differentiated tumor cells. Glioblastoma multiform (GBM), is the most malignant brain tumor, in which its growth and persistence depend on cancer stem cells with enhanced DNA damage repair program that also induces recurrence and resists current chemo- and radio...

Neuroimaging plays a significant role in the diagnosis of intracranial tumors, especially brain gliomas, and must consist of an assessment of location and extent of the tumor and of its biologic activity. Therefore, morphologic imaging modalities and functional, metabolic, or molecular imaging modalities should be combined for primary diagnosis and for following the course and evaluating therap...

background the anti-inflammatory properties of magnesium sulfate have never been discussed in brain tumor surgeries. objectives this study is aimed to find anti-inflammatory aspects of high dose magnesium sulfate infusion during perioperative period of neurosurgical patients through checking the serial c-reactive protein (crp) blood levels as a biomarker of inflammation. patients and methods si...

acoustic neuromas (an) are schwann cell-derived tumors that commonly arise from the vestibular portion of the eighth cranial nerve also known as vestibular schwannoma(vs) causes unilateral hearing loss, tinnitus, vertigo and unsteadiness. in many cases, the tumor size may remain unchanged for many years following diagnosis, which is typically made by mri. in the majority of cases the tumor is s...

introduction: gamma knife is an instrument specially designed for treating brain disorders. in gamma knife, there are 201 narrow beams of cobalt-60 sources that intersect at an isocenter point to treat brain tumors. the tumor is placed at the isocenter and is treated by the emitted gamma rays. therefore, there is a high dose at this point and a low dose is delivered to the normal tissue surroun...

BACKGROUND Outcomes projects can be a catalyst for determining disease- and treatment-related consequences for patients with rare tumors. The Adult Ependymoma Outcomes (AEO) survey uses self-reported experience to evaluate how this tumor affects patient groups throughout the illness trajectory. METHODS Patients completed the AEO survey via a Web-based portal. The survey included questions on ...

Differentiating treatment necrosis from tumor recurrence poses a diagnostic conundrum for many clinicians in neuro-oncology. To investigate the potential role of circulating cells (CTCs) detection differentiating and brain gliomas, we retrospectively analyzed data 22 consecutive patients with totally removed new enhancing mass lesion(s) showed on MRI after initial radiotherapy. The were finally...

Malignant gliomas are associated with high mortality due to infiltrative growth, recurrence, and malignant progression. Even with the most efficient therapy combinations, median survival of the glioblastoma multiforme (grade 4) patients is less than 15 months. Therefore, new treatment approaches are urgently needed. We describe here identification of a novel homing peptide that recognizes tumor...

BACKGROUND AND PURPOSE Differentiation between tumor recurrence and treatment-related brain injury is often difficult with conventional MRI. We hypothesized that the diffusion-weighted imaging (DWI) could help differentiate these 2 conditions, because water diffusion may be greater for necrotic tissues in the treatment-related brain injury than for tumor tissues in recurrence. Our aim was to an...