A new in vivo animal model that produces diffuse brain injuries in sagittal plane rearward rotational acceleration has been developed. In this model, the skull of an anesthetized adult rat is tightly secured to a rotating bar. During trauma, the bar is impacted by a striker that causes the bar and the animal head to rotate rearward; the acceleration phase last 0.4 ms and is followed by a rotati...

objectives we aim to evaluate the role of glibenclamide on the short-term outcome of patients with dai due to moderate to severe tbi. patients and methods in this controlled randomized clinical trial, 40 patients with moderate to severe tbi were assigned to glibenclamide (n = 20) and control (n = 20) groups. six hours after admission the intervention group received 1.25 mg glibenclamide every 1...

Brain foreign bodies and penetrating missile injuries of the brain are familiar topics for Iranian physicians, especially after Iran and Iraq war. But it’s not easily plausible that there is a couple of sewing needles in the cranium of a patient who has not any history of head trauma or penetrating injury. The patient was a 42-year-old man who admitted in neurology ward of Mottahari Hospital in...

Most studies of neuro-functional patterns in trauma-exposed individuals have been conducted considerable time after the traumatic event. Hence little is known about neuro-functional processing shortly after trauma-exposure. We investigated brain activity patterns in response to trauma reminders as well as neutral and negative stimuli in individuals who had recently (within 3 weeks) been involve...

We report one case of brain glioma that developed in the scar of an old brain trauma. A 45-year-old man who presented with seizures; MRI showed a large mass in the right temporal region. Surgical biopsy showed a glioblastoma multiforme. The patient had suffered a cranial trauma in a road accident 10 years previously with an intracerebral hematoma in the right temporal region. This case fulfills...

Microglia is one of the first innate immune components. These cells account about 5 to 10% of the entire adult brain cells and are activated by trauma. Complex-mediated inflammatory responses occur through cellular and molecular events during and after the traumatic brain injury (TBI). In-lesion area astrocytes, microglia, and damaged neurons begin to secrete cytokines and chemokines. Microglia...

Central nervous system injury, specifically traumatic brain and spinal cord can have significant long lasting effects. There are no comprehensive treatments to combat the injury sequalae of events that occurring following a central trauma. Herein we discuss potential for epothilone family microtubule stabilizing agents improve outcomes experimentally induced These drugs, which able cross blood-...

Quantification and analysis of brain contusion was initially done in 1970’s followed by 2005. They derived brain contusion index based on parenchymal depth and surface distribution of contusion over brain. We conducted this study with the objectives of whether severity of contusion index determines Post trauma survival, is there a region specific contusion which determines Post trauma survival ...

BACKGROUND Head trauma is the main cause of disabilities and death among young people, and the side effects of head trauma pose some of the greatest medical challenges. Rapid diagnosis and the use of proper treatments can prevent more severe brain damage. The purpose of this research was to determine the quality of nursing services provided to brain trauma patients in hospitals in Guilan Provin...