The aim of the present work was to assess the effects of activation of NMDA receptors in rat brain in vivo on calcium homeostasis in isolated non-synaptic brain mitochondria. We have shown recently that acute intoxication with large doses of ammonia leads to activation of NMDA receptors in rat brain in vivo. In the present work we injected rats with ammonium acetate to activate NMDA receptors i...

Sex-specific differences in mitochondrial function and free radical homeostasis are reported in the context of aging but not well-established in pathogeneses occurring early in life. Here, we examine if sex disparity in mitochondria function, morphology, and redox status starts early and hence can be implicated in sexual dimorphism in cardiac as well as neurological disorders prevalent at young...

Received 2/13/2001; revised 8/10/2001; accepted 11/1/2001. For correspondence or reprints contact: Jem-Mau Lo, Department of Nuclear Science, National Tsing Hua University, 101 Section 2, Kuang-Fu Road, Hsinchu 300, Taiwan. Tel: (886)3-5727308, Fax: (886)3-5718649, E-mail: [email protected] The intracellular distributions of Tc-d,l-HMPAO, Tcmeso-HMPAO and Tc-PnAO in rat brains were explored i...

Abstract Oncocytic meningioma has been first identified in 1997 as a rare variant, composed predominantly of large meningothelial cells with abundant intracytoplasmic mitochondria. Here, we describe 34-year-old male patient presenting 2 weeks progressive holocranial headache. Brain magnetic resonance imaging (MRI) revealed an extra axial solid-cystic expansive lesion the left parieto-occipital ...

The data presented in this article are related to the research article entitled "Rotenone decreases ischemia-induced injury by inhibiting mitochondrial permeability transition in mature brains" (Rekuviene et al., 2017) [1]. Data in this article present the direct effects of rotenone on calcium retention capacity (CRC) in isolated normal cortex and cerebellum mitochondria, effects of rotenone in...

1. The effect of phenylalanine and phenylpyruvate on the metabolism of pyruvate by isolated mitochondria from rat brain was investigated. 2. Phenylpyruvate inhibited the fixation of H(14)CO(3) (-) in the presence of pyruvate by intact rat brain mitochondria, whereas phenylalanine and other metabolites of this amino acid had no inhibitory effect on this process. 3. Pyruvate carboxylase activity ...

Carbenoxolone (Cbx), a substance from medicinal licorice, is used for antiinflammatory treatments. We investigated the mechanism of action of Cbx on Ca(2+)-induced permeability transition pore (PTP) opening in synaptic and nonsynaptic rat brain mitochondria (RBM), as well as in rat liver mitochondria (RLM), in an attempt to identify the molecular target of Cbx in mitochondria. Exposure to thres...

Mitochondria are central to aerobic energy production and play a key role in neuronal signalling. During anoxia, however, the mitochondria of most vertebrates initiate deleterious cell death cascades. Nonetheless, a handful of vertebrate species, including some freshwater turtles, are remarkably tolerant of low oxygen environments and survive months of anoxia without apparent damage to brain ti...

Objective We present an approach for detecting mitochondria in electron microscopy images of brain tissue and demonstrate it on the rat neuropil. This would enable the study of statistics of mitochondria and their location relative to other structures such as cell boundaries, vesicles and synapses. Neural tissue from the Lateral part of the rat's brain was cut into 50nm slices and photographed ...

It has been argued that in late-onset Alzheimer's disease a disturbance in the control of neuronal glucose metabolism consequent to impaired insulin signalling strongly resembles the pathophysiology of type 2 diabetes in non-neural tissue. The fact that mitochondria are the major generators and direct targets of reactive oxygen species led several investigators to foster the idea that oxidative...