conclusions increased serum levels of interleukins 6 and 8 as a predictive marker might be associated with unfavorable clinical outcome in patients with severe tbi. results comparing the serum levels of interleukins in two groups with favorable and unfavorable clinical outcomes showed that the mean serum levels of interleukins 6 and 8 in group with favorable outcome was 85.2 ± 51.6 and 52.2 ± 3...

Traumatic brain injury (TBI) is a common reason of brain tissue loss as a result of tumors, accidents, and surgeries. Renewal of the brain parenchyma is restricted by many reasons such as inimical substances produced as the result of trauma and also inflammatory responses. A strong cascade of inflammatory responses begins as a result of TBI which include recalling peripheral leukocytes into the...

Traumatic brain injury (TBI) is a major cause of mortality and morbidity worldwide and leads serious longterm disability. To determine the effect of hydrogen-rich water on the angiogenesis in the lesion boundary brain tissue of TBI-challenged rats, 54 adult male Sprague-Dawley (SD) rats were used and randomly divided into three groups: sham-operated, TBI (Traumatic brain injury) and TBI+HW (Tra...

OBJECTIVE Following traumatic brain injury, disruption of blood-brain-barrier and consequent brain edema are critical events which might lead to increasing intracranial pressure (ICP), and nerve damage. The current study assessed the effects of aqueous date fruit extract (ADFE) on the aforementioned parameters. MATERIALS AND METHODS In this experimental study, diffused traumatic brain injury ...

traumatic brain injury (tbi) is an important cause of death and disability in young adults ,and may lead to physical disabilities and long-term cognitive, behavioral psychological and social defects. there is a lack of definite result about the effect of thyroid hormones after traumatic brain injury in the severity and no data about their effect on mortality of the injury. the aim of this study...

Traumatic brain injury (TBI) is amongst the leading causes of morbidity and mortality worldwide. Despite evidence neurogenesis post-TBI, survival integration newborn neurons remains impaired. High Mobility Group Box protein 1 (HMGB1) an ‘alarmin’ released hyper-acutely following TBI implicated in hosting neuro-inflammatory response to injury. It also instrumental mediating under physiological c...

the patient with head trauma is a challenge for the emergency physician and for the neurosurgeon. currently traumatic brain injury constitutes a public health problem. knowledge of the various supportive therapeutic strategies in the pre-hospital and pre-operative stages is essential for optimal care. the immediate rapid infusion of large volumes of crystalloids to restore blood volume and bloo...

An immediate consequence of traumatic brain injury (TBI) is the induction of an inflammatory response. Mounting data suggest that inflammation is a major contributor to TBI-induced brain damage. However, much remains unknown regarding the induction and regulation of the inflammatory response to TBI. In this study we compared the TBI-induced inflammatory response to severe parenchymal injury (co...

Introduction: Brain injury is an important cause of morbidity and mortality worldwide and so far, there has been no absolute treatment for the damaged brain tissue. Using human stem cells with self-assembling scaffolds can be a promising method for treatment of traumatic brain injury. Materials and Methods: Human meningioma stem cells were isolated, cultured and then expanded into in vitro cond...