The influence of the duration of ischemia on the development and resolution of post-ischemic brain edema (SG method) was studied in anesthetized rats. Edema developed during ischemia and the amount of edema was related to the duration of ischemia (r = 0.843, p less than 0.001). With recirculation to three hours, the major determinant of the amount of edema was still the duration of the precedin...

introduction: following a traumatic brain injury (tbi), the excessive release of proinflammatory cytokines is major cause of cerebral edema that can cause permanent neuronal loss. this study examined the changes in brain concentrations of proinflammatory cytokines il-1, il-6, tnf-α and tgf- after different doses of estrogen or progesterone treatment in brain-injured rats at 6 and 24 h post-in...

OBJECTIVE We aimed to clarify the optimal timing for the fluorescence imaging of brain tumor tissue differentiated from brain edema after the administration of photosensitizers. METHODS We have performed an in vivo study of the kinetics of 5-aminolevulinic acid (5-ALA) in comparison with talaporfin sodium using the rat brain tumor model and rat vasogenic edema model produced by cold injury. T...

background: stroke is the third leading cause of invalidism and death in industrialized countries. there are conflicting reports about the effects of angiotensin ii on ischemia-reperfusion brain injuries and most data have come from chronic hypertensive rats. in this study, hypotensive and non-hypotensive doses of candesartan were used to investigate the effects of angiotensin ii at1 receptor b...

BACKGROUND AND PURPOSE Brain edema is a life-threatening consequence of stroke and leads to an extension of the affected tissue. The space-occupying effect due to brain edema can be quantified in rat stroke models with the use of MRI. The present study was performed to test 2 hypotheses: (1) Can quantification of the space-occupying effect due to brain edema serve as a noninvasive measure for b...