The blood brain barrier (BBB) refers to the complex anatomical barrier in the brain composed of endothelial cells, astroglia, pericytes, perivascular macrophages and basal lamina. Its selectivity controls the entry of substances into the Central Nervous System (CNS) [1]. BBB disruption affects neurodegeneration [2] and in some cases can be harnessed to deliver intravenous therapeutics to the CN...

The blood-brain barrier (BBB) serves as a highly selective barrier separating the central nervous system from the systemic circulation. Although contributing to neurological health, the BBB restricts the ability of drugs to reach their site of action and thus presents a major challenge to the treatment of neurological disorders. Advances in our understanding of the complexity of the BBB have fo...

A central nervous system (CNS) site of action generally requires that, following entry into the systemic circulation, substances must interact with the blood-brain barrier (BBB) en route to brain tissue targets. Many substances with CNS activity, including drugs of abuse, cross the BBB by simple passive diffusion (Oldendorf 1974; Levin 1980; Cornford et al. 1982). Accordingly, the BBB plays an ...

Brain-targeted drug delivery is a field of research that seeks to develop new methods for delivering drugs the brain. This done by overcoming blood-brain barrier (BBB), network cells tightly regulate flow substances between blood and Most time lipophilic are easily cross brain but few them less soluble in lipid therefore they don’t barrier. After review we concluded can improve solubility using...

The blood-brain barrier (BBB) is a transport that suppresses the translocation of potentially harmful substances to brain tissue. Although BBB known be associated with many kinds neuropathology, such as neuroinflammation and neurodegenerative diseases, conventionally used animal Transwell models cannot provide sufficient information due genetic functional heterogeneity in comparison humans limi...

Brain metastasis is one of the most deadly types of metastasis, frequently seen as a result of cancer spread from lung cancer, breast cancer and malignant melanoma. A key cellular structure in controlling brain metastasis is the blood-brain barrier (BBB). The BBB is known to protect metastatic tumour cells from chemotherapy and antitumor immunity. On the other hand, the BBB is also a key cellul...

BLOOD-BRAIN BARRIER PERMEABILITY STUDIES Ross Booth and Hanseup Kim Electrical and Computer Engineering, Bioengineering University of Utah, Salt Lake City, UT ABSTRACT The blood-brain barrier (BBB) blocks most compounds from entering the central nervous system (CNS), limiting the success rate of new treatments of CNS disease. Insight needed to overcome these limitations can be gained through in...

More than a century ago, Paul Ehrlich demonstrated in a set of dye experiments the lack of permeability of intracerebral vessels to albumin-binding dyes and therefore postulated a barrier between blood and neuronal tissue. Indeed, transport across the blood-brain barrier (BBB) is tightly regulated by at least four different cells that comprise the brain microvascu-lature: the endothelial cell a...

Multiple sclerosis (MS) is a progressive inflammatory disease of the central nervous system (CNS) leading to severe neurological deficits. To date, no treatment is available that halts disease progression, but clinical symptoms can be generally improved by therapies involving anti-inflammatory and/or immune modulatory reagents, which may cause off-target effects. Therefore, there remains a high...

The aim of the present study was to develop a blood-brain barrier (BBB) permeability model that is applicable in the drug discovery phase. The BBB ensures proper neural function, but it restricts many drugs from entering the brain, and this complicates the development of new drugs against central nervous system diseases. Many in vitro models have been developed to predict BBB permeability, but ...