Introduction: There are several different molecular pathways in tissue damage by Ischemic Brain Injury. The use of antioxidants and free radical scavengers are a matter of attention by some researchers. Crocus sativus (saffron) is used previously for protective effects in ischemia state by some researchers. To assess pathologic aspects of neuroprotection of saffron in some susceptible brain are...

extensive research in the last decade has defined that most chronic diseases display dysregulation of multiple cell signaling pathways that have been linked to inflammation. neuroinflammation is reaction of living nervous tissue to injury. it may be initiated in response to neurological disease. including infection, traumatic brain injury, toxic metabolites and autoimmunity. the natural compoun...

The high nutritional content in catfish oil can be a rich source of omega-3 fatty acids, which function the development child's brain. However, acid causes fish to become more susceptible oxidation during storage process, prevented by adding antioxidants. This study aims determine quality after ginger as an antioxidant. method used is titration peroxide value and number free acids. results obta...

Oxidative stress is thought to play a role in the onset of dementia. HIV-dementia has recently been demonstrated to be associated with oxidative stress as indexed by increased protein and lipid peroxidation in the brain and cerebrospinal fluid compared to HIV non-demented patients. The HIV protein Tat induces neurotoxicity, and, more recently, Tat was found to induce oxidative stress directly a...

1. Fresh ox-brain homogenate prepared under standard conditions at 4°C and stored at 20°C autoxidizes spontaneously and reproducibly when re-heated to 37°C. 2. The preparation can be used for assaying the antioxidant activity of serum and of other biological fluids. The preparatory and assay procedures are described. 3. The antioxidant activity of normal serum, cerebrospinal fluid, synovial flu...

Autism has attracted much attention in recent years, both in research and in the media. This review summarizes evidence for important involvement of electron transfer (ET), reactive oxygen species (ROS), oxidative stress (OS), antioxidants (AOs) and genes. Evidence points to a key role for pollution. The fetus is the stage most susceptible to damaging effects, mostly to the brain and central ne...

Introduction Antioxidant defenses are involved in protecting against dementia and neurodegenerative disease. Vitamin C (ascorbate) and glutathione (GSH) are the two most concentrated chemical antioxidants in the human central nervous system [1]. While human brain region specific ascorbate concentration ([Asc]) changes have been measured post mortem as a function of age [2], studies in young rat...