Introduction: Various bone palliative therapeutic agents have been developed and widely used for bone metastasis such as 153Sm-EDTMP. In this study, production, quality control and biodistribution studies of a newly developed therapeutic compound have been presented followed by imaging studies in wild-type rodents. Methods: 153Sm-TTHMP was prepared starting from 153<...

in this paper, preparation, bioactivity, and osteoblast cell behavior of cortical bone derived nanobiphasic calcium phosphate (nano-bcp) are presented. the calcined bovine bone samples with the addition of di-ammonium hydrogen phosphate were heated at 700°c for 100 min, and thus nano-bcp with the composition of 63/37 hydroxyapatite (ha)/β-tricalcium phosphate (β-tcp) was produced. scanning elec...

In 2000, human skeletal remains were discovered in Split (Croatia). As archaeologists confirmed, it was an ancient skeleton accompanied by ceramics and bracelet characteristic for late Roman period whose possible violent death was excluded. The bone sample was radiocarbon dated by AMS to 1750 years. DNA was successfully extracted from the bone sample and subsequently typed using mt DNA and STR ...

Systematic excavations at the site of the Sima de los Huesos (SH) in the Sierra de Atapuerca (Burgos, Spain) have allowed us to reconstruct 27 complete long bones of the human species Homo heidelbergensis. The SH sample is used here, together with a sample of 39 complete Homo neanderthalensis long bones and 17 complete early Homo sapiens (Skhul/Qafzeh) long bones, to compare the stature of thes...

Efforts in finding independent measures for accurate and reliable prediction of trabecular bone failure have led to the development of a number of morphometric indices characterizing trabecular bone microstructure. Generally, these indices assume a high homogeneity within the bone specimen. However, in the present study we found that the variance in bone volume fraction (BV/TV) in a single bone...

The best way to preserve mechanical properties of bone for biomechanical testing is hydration in NaCl whereas the reference process in μCT analysis is defatting. The aim of our study was to evaluate the effects of sample conditioning on trabecular bone microarchitecture comparing defatted specimens (considered as reference for μCT analysis) with two hydrated modes (considered as references for ...

Electrostimulative fields are used to accelerate bone regeneration after fractures and to treat bone diseases. Most of these systems have upper and lower thresholds for electromagnetic fields, which have proven to have a positive effect towards bone growth. The biomechanical background, however, is still subject of ongoing research. Using numerical simulation, this paper investigates the field ...

intraosseous ganglia can affect the carpal bones of the hand and must be considered in the differential diagnosis of wrist pain. a 38-year-old female presented with a 14-month history of left wrist pain and a radiolucent cystic lesion was seen computed tomography (ct) scanning. characteristic radiographic findings of a cyst in association with a fine sclerotic rim was apparent. we report an unu...