BACKGROUND This study aims to investigate the biocompatibility and in vivo osteogenic capability of the novel bone tissue engineering scaffold apatite-wollastonite-magnetic glass ceramic/chitosan (A-W-MGC/CS). METHODS Rabbit bone marrow stromal cells (BMSCs) were transfected with adenovirus-human bone morphogenetic protein-2-green fluorescent protein (Ad-hBMP2-GFP). The transfected BMSCs were...

................................................................................................................................. vii CHAPTER 1 GENERAL INTRODUCTION ............................................................ 1 1.1 General Principles of Equine Fracture Repair........................................................ 2 1.2 Bone Structure and Function. Bone Healing....................

Bone healing after fracture occurs in a well-organized manner and involves a multitude of cell types, inflammatory cytokines, growth factors, prostaglandins, and certain vitamins. Some of the means by which alterations in these essential components affect bone repair are understood, whereas others still need to be delineated. Based on clinical experience and basic science research, certain clin...

Studies have shown that tendon insertion site injuries can lead to bone loss. Following tendon-bone repair, bone loss can lead to widening of the repair tunnel. This widening may negatively affect the establishment of a strong tendon-bone interface, leading to recurrence of failure. Our goal was to suppress bone loss after insertion site repair using alendronate in an attempt to prevent the dec...

Summary An 8‐month‐old Thoroughbred filly presented for surgical repair of a fracture the right olecranon. Fixation with an orthopaedic plate and screws was attempted, complications intraoperative haemorrhage poor bone viability. The euthanised 5 days after repair, following post‐operative secondary fracture. Primary hepatoblastoma liver metastasis humerus, radius ulna were diagnosed at necrops...

Alterations of the subchondral bone are pathological features associated with spontaneous osteochondral repair following an acute injury and with articular cartilage repair procedures. The aim of this review is to discuss their incidence, extent and relevance, focusing on recent knowledge gained from both translational models and clinical studies of articular cartilage repair. Efforts to unrave...

Murine models of bone marrow transplantation show that pre-conditioning regimens affect the integrity of the bone marrow endothelium and that the repair of this vascular niche is an essential pre-requisite for successful haematopoietic stem and progenitor cell engraftment. Little is known about the angiogenic pathways that play a role in the repair of the human bone marrow vascular niche. We th...