Osteoclasts are unique multinucleated cells formed by fusion of preosteoclasts derived from cells of the monocyte/macrophage lineage, which are induced by RANKL. However, characteristics and subpopulations of osteoclast precursor cells are poorly understood. We show here that a combination of TNF-α, TGF-β, and M-CSF efficiently generates mononuclear preosteoclasts but not multinucleated osteocl...

Previous studies have suggested that kidney donors may have abnormalities of mineral and bone metabolism typically seen in chronic kidney disease. This may have important implications for the skeletal health of living kidney donors and for our understanding of the pathogenesis of long-term mineral and bone disorders in chronic kidney disease. In this prospective study, 182 of 203 kidney donors ...

Bone metastasis is a frequent finding in the natural history of several types of cancers. However, its anticipated risk, diagnosis and response to therapy are still challenging to assess in clinical practice. Markers of bone metabolism are biochemical by-products that provide insight into the tumor-bone interaction, with potential to enhance the clinical management of patients with bone metasta...

BACKGROUND The decoction combination of Herba Epimedii and Fructus Ligustri Lucidi has been used to treat osteoporosis for almost 50 years by practitioners of traditional Chinese medicine. However, it is unclear what specific effects this combination of herbs has on the skeleton. The aim of this study was to assess the effects of the combined extracts from Herba Epimedii and Fructus Ligustri Lu...

Metabolism of the bone healing process can be monitored by Bone formation marker, such as alkaline phosphate (ALP). Simvastatin is known to increase marker in repair phase, but its effects on ALP level have not been yet. This study aimed determine effect oral simvastatin administration expression femur fracture a rat model fracture. The research method was experimental post-test only using 18 R...

of vitamin K were not affected by fractures in its acute phase. Bone formation markers did not change during the acute phase of hip fracture. Bone resorption markers increased on the third day. Biochemical markers of bone turnover were not affected for at least 48 h after fracture. Therefore, the values of those measurements during the first 48 h after fracture appear to reflect bone metabolism...

Expression of SH2 domain-containing leukocyte-specific phosphoprotein of 76 kDa (SLP-76), a hematopoietic cell-specific adapter protein, is required to couple Syk family tyrosine kinase activation to downstream mediators such as phospholipase C (PLC)-gamma following TCR, platelet collagen receptor and mast cell Fc epsilon R stimulation. In addition to T cells, mast cells and platelets, SLP-76 i...

Infection of murine bone marrow-derived macrophages (BMM ) with Chlamydia pneumoniae induces IFN-dependent IFNsecretion that leads to control of the intracellular bacterial growth. Enhanced growth of C. pneumoniae in Toll-like receptor (TLR) 4 / and myeloid differentiation factor (MyD) 88 / (but not TLR2 / , TLR6 / , or TLR9 / ) BMM is shown in this study. Reduced accumulation of IFNand IFNmRNA...