نتایج جستجو برای: bone marrow micronucleus assay

تعداد نتایج: 525765  

Introduction: In this study, the effect of para-nonylphenol as an environmental pollutant on viability, morphology and proliferation of bone marrow mesenchymal stem cells was investigated. Methods: Bone marrow mesenchymal stem cells of rat were treated with the 0.5, 1, 2.5, 3.5 and 5 μM of paranonylphenol for a period of 21 days, then the viability of the cells were estimated using trypan bl...

Journal: :journal of paramedical sciences 0
fatemeh sabagh department of basic sciences, faculty of paramedical sciences,shahid beheshti university of medical sciences,tehran michael roggendorf institute of medical virology, university clinic essen

adenoviruses are recognized as common human pathogens that are responsible for a wide variety of infectious syndromes. bone marrow transplant patients are prone to life threatening opportunistic infections like adenoviruses. the nested polymerase chain reaction has provided an alternative, sensitive diagnostic method for detection of adenoviruses. in this study we developed pcr from hexon genes...

2018
Takao HASHIMOTO

.....The mutagenic potential o ξ thiamazole , an antith ア agent , was investigated bア an in vivo cytogenetic test and was compared with those of mitomycin C and vincristin . These drugs were subcutaneously inlected into slc −ICR male mice e童ther as a single dose or asmult 三ple doses for 5succcssive days, Thiamazole(900r 180 mg /kg)dld not increase the number of micronucl...

Journal: :Journal of pharmaceutical research international 2021

Background: In recent years, there has been a surge in interest studying plant-derived materials and their impact on DNA. Herbal products include number of natural substances that may help protect cells against mutagen-induced cell damage.
 Aim: The purpose this research was to assess the genotoxic effects Cassia Auriculata Linn flavonoids (CAF) saponin (CAS) rich fractions mouse bone marr...

Journal: :Mutation research 2011
Priscila de Matos Cândido-Bacani Mariana Bisarro dos Reis Juliana Mara Serpeloni Tamara Regina Calvo Wagner Vilegas Eliana Aparecida Varanda Ilce Mara de Syllos Cólus

Isatin (1H-indole-2,3-dione) is a synthetically versatile substrate used for the synthesis of heterocyclic compounds and as a raw material for drug synthesis. Isatin and its derivatives demonstrate anticonvulsant, antibacterial, antifungal, antiviral, and anticancer properties. We evaluated the genotoxic and mutagenic effects of acute (24h) and repeated (14d) exposure to isatin in vivo, using t...

Journal: :Mutagenesis 2011
Takeshi Morita James T MacGregor Makoto Hayashi

This report updates previous reviews that were conducted as part of the third and fourth International Workshops on Genetic Toxicology Testing of micronucleus (MN) assays in rodent tissues other than bone marrow. Tissues discussed here are liver, lung, skin, colon, spleen, testes and foetal/neonatal tissues with transplacental exposure. Previous reviews have been updated to include literature p...

Journal: :physiology and pharmacology 0
mohammad husein abnosi biology dept. faculty of sciences. arak university, arak, iran. malek soleimani mehranjani biology dept. faculty of sciences. arak university, arak, iran. sayed mohammad ali shariatzadeh biology dept. faculty of sciences. arak university, arak, iran. majid mahdiyeh najafabadi biology dept. faculty of sciences. arak university, arak, iran. laila dehdehi biology dept. faculty of sciences. arak university, arak, iran.

introduction: in this study, the effect of para-nonylphenol as an environmental pollutant on viability, morphology and proliferation of bone marrow mesenchymal stem cells was investigated. methods: bone marrow mesenchymal stem cells of rat were treated with the 0.5, 1, 2.5, 3.5 and 5 μm of paranonylphenol for a period of 21 days, then the viability of the cells were estimated using trypan blue ...

Journal: :مجله بین المللی زیست و زیست پزشکی 0
zeynab dadgar department of biology, arak university, arak, iran nargess abdali student research committee & razi herbal medicines research center, lorestan university of medical sciences, khorramabad, iran abolfazl elyasi irai young researchers and elite club, ayatollah amoli branch, islamic azad university, mazandaran iran zeinab salehian gen fanavar q co, biotechnology incubator center, pasteur institute of iran (north research center), amol, mazandaran, iran

this investigation aimed to examine the protective function of vitamin e on rat bone marrow mesenchymal stem cells (mscs) treated with cadmium chloride. rat bone marrow mscs were extracted using flashing-out and cultured in dmem containing 10% fbs and 100 u/ml pen/strep. at the end of the third passage, cells were divided into 4 groups including control, cadmium chloride, cadmium chloride + vit...

Ali Shabestani Monfared Aziz Mahmodzade Hossein Mozdarani, Mahdi Pouramir Saba Nadi

Background: Interactions of free radicals from ionizing radiation with DNA can induce DNA damage and lead to mutagenesis and carsinogenesis. With respect to radiation damage to human, it is important to protect humans from side effects induced by ionizing radiation.In the present study, the effects of arbutin were investigated by using the micronucleus test for anti-clastogenic activity, to cal...

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