OBJECTIVES To determine whether red blood cell transfusion is similarly associated with nosocomial infections in pediatric intensive care unit patients and whether reduced lymphocyte numbers is a possible mechanism. In adult studies, red blood cell transfusions are associated with nosocomial infections. DESIGN Historical cohort study. SETTING Single-center, mixed medical-surgical, closed pe...

adenoviruses are recognized as common human pathogens that are responsible for a wide variety of infectious syndromes. bone marrow transplant patients are prone to life threatening opportunistic infections like adenoviruses. the nested polymerase chain reaction has provided an alternative, sensitive diagnostic method for detection of adenoviruses. in this study we developed pcr from hexon genes...

Homeostasis in the central nervous system (CNS) is maintained by active interfaces between the bloodstream and the brain parenchyma. The blood-brain barrier (BBB) constitutes a selective filter for exchange of water, solutes, nutrients, and controls toxic compounds or pathogens entry. Some parasites, bacteria, and viruses have however developed various CNS invasion strategies, and can bypass th...

Many factors are involved in our ability to understand the complex role of the blood recipient in cytomegalovirus infections. The age factor is an extremely important one. The neonate does not have a fully developed immunological system and is not able to respond as well as the mature individual. The young child has an intact immune system but has had only limited experience with infectious age...

The recent studies by Paya et al. (2) concluded that quantitative blood cultures were not useful in diagnosing intravascular-device-related bacteremia associated with arterial, central venous, and pulmonary artery catheters. While obviously more work needs to be done on the value of aspiration through a catheter in the diagnosis of catheterassociated sepsis, a number of studies have found this ...

1. A study was made of the behavior of the blood platelets during the course of pneumonia in man, as also in several rabbits experimentally infected with pneumococci. 2. The number of platelets begins to diminish after the infection has become established. A thrombopenia occurs during the febrile period. Immediately following the onset of the crisis in lobar pneumonia or after the temperature b...

Modifications in donor screening and the introduction of laboratory testing of donated blood for anti-HIV-1 and anti-HTLV-I have resulted in a significant reduction in the risks of retroviral infections from blood transfusion. Presently, the American Red Cross detects an average of eight carriers of human immunodeficiency virus, type 1 (HIV-1) per 100,000 otherwise acceptable blood donors (0.00...

Dear Sir, Cancer patients are at an increased risk of the blood stream infections (BSI) due to their immune‐compromised status, repeated hospitalizations, and various procedures. Staphylococci, particularly coagulase negative Staphylococci (CoNS) are noteworthy pathogens in such cases, and the emergence of multi‐drug resistance in Staphylococci is a cause of concern. This study was prospectivel...

Bloodstream infections (BSIs) are associated with adverse clinical and health-economic outcomes [1,2]. Th irty to forty percent of all cases of severe sepsis and septic shock are culture-proven BSIs, for which there is a rapid decline in survival rates in cases where inadequate antimicrobial therapy is administered within the fi rst 24 hours [3,4]. As a consequence, clinicians often resort to e...