rheumatoid arthritis (ra) is a chronic inflammatory disorder characterized by joint swelling, synovial inflammation and joint destruction. curcumin (diferuolymethane) is the most active component of curcuma longa l. several clinical trials have indicated curcumin to be a notable anti-inflammatory and antioxidant compound. therefore the aim of this study is investigating the effects of curcumin ...

background: the early stage of copper poisoning is difficult to be clinically diagnosed in sheep and has not been documented clearly yet. objectives: to assess biomarkers in predicting early copper poisoning in sheep, blood samples were collected from several groups of animals from a naturally copper poisoning occurrence in an industrial region. methods: animals were divided into four experimen...

The distinction between causes of acute infections is a major clinical challenge. Current biomarkers, however, are not sufficiently accurate. Human neutrophil lipocalin (HNL) concentrations in serum or whole blood activated by formyl-methionine-leucine-phenylalanine (fMLP) were shown to distinguish acute infections of bacterial or viral cause with high accuracy. The aim was therefore to compare...

The nonspecific and variable presentation of traumatic brain injury (TBI) has motivated an intense search for blood-based biomarkers that can objectively predict the severity of injury. However, it is not known how cytosolic proteins released from traumatized brain tissue reach the peripheral blood. Here we show in a murine TBI model that CSF movement through the recently characterized glymphat...

Blood-based biomarkers related to Alzheimer’s disease (AD) have significant potential to advance both the diagnostic and therapeutic processes and procedures related to this devastating disease. In light of this potential, a significant amount of work has been conducted in recent years. In fact a PubMed search (6/2016) using the terms “blood based biomarkers AND Alzheimer’s disease” yielded 474...

Alzheimer's disease (AD) is the most important cause of dementia in the elderly. The molecular alterations preceding this neurodegenerative pathology may take place even 20 years before its clinical appearance. In this context, the discovery of biomarkers in biological fluids enabling an early presymptomatic diagnosis as well as discrimination from other types of dementia is eagerly awaited. In...