Heart failure is associated with an adverse prognosis, and aggressive therapy is needed. In most patients, medical therapy is the cornerstone of treatment. Although the response to medical therapy is good in heart failure patients, benefit varies significantly among individual patients. This has been particularly demonstrated for beta-blocker therapy. Packer and colleagues evaluated .2000 heart...

A condition of motor restlessness ranging from a feeling of inner disquiet to inability to sit or lie quietly or to sleep.Called also acathisia, akithisia, and Kathisiophobia (1). The term ''Akathisia" was created by Haskovec in 1901. Haase first applied the term (1955) to the inability to sit still and to the other irri­tative hyperkinetic symptoms that are sometimes seen as a complication of ...

PURPOSE To assess the efficacy of one course of rituximab (two 1-g doses) compared to an alternative tumor necrosis factor-α (TNFα) blocker in rheumatoid arthritis patients who had experienced one previous TNFα blocker failure (eg, etanercept, adalimumab, or infliximab). PATIENTS AND METHODS The efficacy of both treatments was studied in this retrospective, multicenter, noninterventional coho...

Alpha-adrenoceptor antagonists (alpha-blockers) are widely prescribed to treat lower urinary tract symptoms (LUTS) in men but fail to ameliorate LUTS sufficiently, especially the storage symptoms related to frequency, urgency and nocturia. We performed a meta-analysis of randomised controlled trials (RCTs) comparing an alpha-blocker plus muscarinic antagonist with an alpha-blocker alone in male...

Overdoses of β-blockers and calcium channel blockers can produce significant morbidity and mortality, and conventional therapies often do not work as treatments for these poisonings. High-dose insulin/glucose therapy has been successful in reversing the cardiotoxic effects of these drugs in cases where the standard therapies have failed, and it appears to be relatively safe. Many successes have...

OBJECTIVES The purpose of this study was to determine the antihypertensive agent(s) more likely to mitigate an exaggerated rise in exercise blood pressure (BP) in hypertensive patients. BACKGROUND An exaggerated rise in exercise BP is associated with increased cardiovascular risk. There are no recommendations for treating such response. METHODS Participants were hypertensive men (n = 2,318;...

This case report describes the first reported overdose of the dihydropyridine calcium channel blocker (CCB) lercanidipine. A 49 yr old male presented to the Emergency Department 3 hrs after the ingestion of 560 mg of lercanidipine. In the department he had a witnessed seizure within 15 minutes of arrival attributed to the overdose. Following immediate recovery of consciousness after the seizure...

INTRODUCTION. High-dose insulin therapy, along with glucose supplementation, has emerged as an effective treatment for severe beta-blocker and calcium channel-blocker poisoning. We review the experimental data and clinical experience that suggests high-dose insulin is superior to conventional therapies for these poisonings. PRESENTATION AND GENERAL MANAGEMENT. Hypotension, bradycardia, decrease...

Abstract Introduction Landiolol is a recently innovated ultra-short-acting beta-blocker. the only beta-blocker with specific dose recommendation for patients cardiac dysfunction and acute atrial fibrillation (Class I according to ESC guidelines). has shorter elimination half-life than any other beta-blocker, it can be administered safely various tachyarrhythmias. The short duration of action ti...