Many patients experience pain and discomfort after colonoscopy. Carbon dioxide (CO(2)) can reduce periprocedural pain although air insufflation remained the standard procedure. The objective of this double-blinded, randomized controlled trial was to evaluate whether CO(2) insufflation does decrease pain and bloating during and after colonoscopy compared to room air. Methods. 219 consecutive pat...

conclusions the results of the study were indicative of improvement and symptom relief in the majority of patients and it seems that treatment prolongation up to six months could be a key factor to achieve better clinical responses. it is recommended that further randomized clinical trials evaluate this therapeutic regimen. background the current study aimed to evaluate the efficacy of mesalazi...

background: the majority of dyspeptic patients do not have identifiable disease, which is also known as functional dyspepsia. the therapeutic approach to patients with functional dyspepsia is still a matter of debate; prokinetic agents are commonly used for symptom relief. this study aims to evaluate the efficacy of domperidone and pyridostigmine (an inhibitor of cholinesterase) in patients wit...

Aims. The association between Helicobacter pylori (H. pylori) infection and diarrhea-predominant irritable bowel syndrome (IBS-D) is still controversial. Here we performed a retrospective study to explore this issue. Methods. A total of 502 inpatients with Rome III confirmed IBS-D and known H. pylori status from 8 hospitals were enrolled. H. pylori-positive patients, hospitalized in the recent ...

Copyright  2015 irjpbs Objective: To compare the efficacy and safety of levosulpiride with dompenidone in patients with functional dyspepsia Material & Method: It was a prospective, double blind, randomized study conducted on 182 patients in two groups of 91 each. Group A: levosulpiride 25mg TID daily orally for 4 weeks, Group B: Domperidone 10mg TID daily orally for 4 weeks. Individual sympto...

INTRODUCTION To improve understanding of the diabetic gastroparesis (DGP) patient experience and inform the patient-reported outcome measurement strategy for future trials in DGP, qualitative interviews were conducted with participants in a phase 2 clinical trial of a novel DGP treatment. METHODS Trial participants were invited to participate in interviews at both the pretreatment visit (PTV)...

BACKGROUND Irritable bowel syndrome (IBS) is a very common functional gastrointestinal (GI). Diagnosis of IBS is based on the fulfilment of the Rome III criteria. Common GI symptoms are lower abdominal pain, bloating and disturbed defecation, such as urgent diarrhoea and/or episodes of chronic constipation. Many agents have been employed in the management of IBS, although only few have been dem...

INTRODUCTION Irritable bowel syndrome (IBS) is characterized by recurrent abdominal pain, bloating, and changes in bowel habit. AIMS To determine the clinical effectiveness of the antispasmodic agents available in Mexico for the treatment of IBS. METHODS We carried out a systematic review and meta-analysis of randomized controlled clinical trials on antispasmodic agents for IBS treatment. C...