Several essential oil samples from dried flower-heads of Chamomilla recutita (L.) Rauschert, grown and commercially available around Curitiba metropolitan area, South of Brazil, were analyzed by GC-MS and the chemical constituents were compared with an Egyptian sample obtained under similar conditions and used as a control. The local grown herbs showed levels of essential oil below the standard...

Epidermal melasma is a common hyperpigmentation disorder that can be challenging to treat. Although current treatment options for melasma are limited, topical skin-lightening preparations have widely been used as alternatives to hydroquinone. In this prospective, single-arm, open-label study, treatment of epidermal melasma with a novel cream formulation containing nicotinamide 4%, arbutin 3%, b...

The present study describes the phytochemical profile and antimicrobial activity of Matricaria chamomilla essential oil. The sample of essential oil was obtained from the aerial parts of the plant by hydrodistillation and analyzed by GC–MS. A total 55 compounds were identified mainly including α-Pinene (22.11%), Camphene (10.8%), Sabinene (4%), Limonene(5.64%),1,8-Cineole(6.45%), Camphor (4%) a...

OBJECTIVE Vanillosmopsis arborea Baker (Asteraceae) has high economic value from Chapada to Araripe and its bark essential oil is a potential source of alpha-bisabolol. The present study aimed to elucidate the antinociceptive and antipruritic properties of the essential oil of V. arborea Baker (EOVA) in mice. MATERIALS AND METHODS The antinociceptive activity was assessed using the capsaicin,...

nitric oxide is a short-lived mediator, which can be induced in a variety of cell types and produces many physiologic and metabolic changes in target cells. it is important in many biological functions and generated from l-arginine by the enzyme nitric oxide synthase. nitric oxide conveys a variety of messages between cells, including signals for vasorelaxation, neurotransmission and cytotoxici...

The Mikania genus has been known to possess numerous pharmacological activities. In the present study, we aimed evaluate interaction of 26 selected constituents species with (i) cyclooxygenase 2 (COX 2), (ii) human neutrophil elastase (HNE), (iii) lipoxygenase (LOX), matrix metalloproteinase ((iv) MMP and (v) 9), (vi) microsomal prostaglandin E synthase (mPGES 2) inhibitors using an in silico a...