REPEAT biopsies are commonly performed in the encouraged to reduce the morbidity of prostate diagnostic setting and increasingly for men on active surveillance. A prior study using SEER (Surveillance, Epidemiology, and End Results)Medicare data reported that 11.8% of men with a negative prostate biopsy underwent repeat biopsy within 1 year and 38% did so within 5 years. A major problem is the s...

OBJECTIVES The various prostate biopsy methods are usually compared in terms of the diagnosis rate of prostate cancer. However, the prevalence of cancer in patients with a negative prostatic biopsy is not usually known. We determined the sensitivity and detection rate of 12-core transperineal biopsies in patients not previously investigated for prostate cancer. METHODS We performed prostate b...

BACKGROUND Biopsy Gleason score (GS), in combination with other clinical parameters, is important to take a therapeutic decision for patients with diagnosis of localized prostate cancer. However, preoperative GS is often upgraded after a radical prostatectomy. Increasing the amount of tissue in prostate biopsy may be a way to avoid this issue. We evaluate the influence of a larger biopsy needle...

OBJECTIVE To prospectively assess safety outcome of TRUS guided prostate biopsy in patients taking low dose aspirin. MATERIALS AND METHODS Consecutive patients, who were planned for 12 core TRUS guided prostate biopsy and satisfied eligibility criteria, were included in the study and divided into two Groups: Group A: patients on aspirin during biopsy, Group B: patients not on aspirin during b...

CONTEXT Prostate biopsy is commonly performed for cancer detection and management. The benefits and risks of prostate biopsy are germane to ongoing debates about prostate cancer screening and treatment. OBJECTIVE To perform a systematic review of complications from prostate biopsy. EVIDENCE ACQUISITION A literature search was performed using PubMed and Embase, supplemented with additional r...

UNLABELLED Study Type - Disagnostic (exploratory cohort) Level of Evidence 2b. What's known on the subject? and What does the study add? Many patients undergo serial biopsy with a low rate of detection of prostate cancer, and the rate of detection declines as more biopsies are pursued. Furthermore, the clinical significance of detected cancer appears to decline as well. It is important to follo...

results a total number of 43 specimens were studied, from which 9 were obtained from patients with metastatic prostate cancer. the expression of five examined genes had no correlation with psa level and gleason score. the expression of amacr decreased in metastatic prostate cancer (p = 0.02). the expression of other genes showed no difference between metastatic and non-metastatic tumors (p > 0....

PURPOSE The sensitivity and specificity of prostate-specific antigen (PSA) alone to select men for prostate biopsy remain suboptimal. This review aims at presenting a review of current prostate cancer (PCa) nomograms that incorporate Prostate Cancer Gene 3 (PCA3), which was designed to outperform PSA at predicting biopsy outcome. MATERIALS AND METHODS The PubMed database and current literatur...

BACKGROUND Understanding men's experience of prostate biopsy is important as the procedure is common, invasive and carries potential risks. The psychological aspects of prostate biopsy have been somewhat neglected. The aim of this study was to explore the level of regret experienced by men after prostate biopsy and identify any associated factors. METHODS Men attending four clinics in Republi...

BACKGROUND The aim of the study was the determination of the negative predictive value of sextant core prostate biopsy. PATIENTS AND METHODS Prostate cancer was diagnosed in 126 patients by systematic ultrasound-guided sextant biopsy and was subsequently treated with radical prostatectomy. The prostatectomy specimens were examined histopathologically using the whole-mount section technique. ...