Biologically triggered exploding microcapsules were synthesized by layer-by-layer assembly of biopolymers. The microcapsules showed controlled rupturing behaviour upon exposure to a pathologically relevant biomolecule, trypsin. These microcapsules offer significant potential for clinical applications.

background : development of new natural agents for parasitic diseases treatment has unexpec­tedly increased to overcome effectively against emergence and re-emergence of parasitic diseases, the appearance of drug resistant organisms and toxic side effects of current agents. the aim of the study was to evaluate antiprotozoal activities of chitosan biomolecule on trophozoites of trichomo­nas gall...

The subphase adsorption behavior and the morphology of trypsin enzyme, lysozyme cytochrome C protein, glucose oxidase present on Langmuir monolayer organo-modified single-wall carbon nanotubes (SWCNTs) were investigated. Furthermore, we estimated maintenance characteristics three-dimensional structure SWCNT film-adsorbed biomolecules when exposed to a high-temperature environment. In this study...

One fascinating recent avenue of study in the field of synthetic biology is the creation of biomolecule-based computers. The main components of a computing device consist of an arithmetic logic unit, the control unit, memory, and the input and output devices. Boolean logic gates are at the core of the operational machinery of these parts, and hence to make biocomputers a reality, biomolecular l...

Drug–biomolecule interactions in the excited state are relevant from a photobiological point of view as they can be correlated with a number of photosensitization disorders such as photocarcinogenicity, photoallergy, phototoxicity, etc. Nonsteroidal antiinflammatory 2-arylpropionic acids and antibacterial fluoroquinolones have been selected as typical examples of photoactive drugs. Protein phot...

In this paper, we propose the SPR (sparse phase retrieval) method, which is a new phase retrieval method for coherent x-ray diffraction imaging (CXDI). Conventional phase retrieval methods effectively solve the problem for high signal-to-noise ratio measurements, but would not be sufficient for single biomolecular imaging which is expected to be realized with femto-second x-ray free electron la...

The conjugation of biomolecules such as proteins and peptides to semiconductor quantum dots (QD) is a critical step in the development of QD-based imaging probes and nanocarriers. Such protein-QD assemblies can have a wide range of biological applications including in vitro protein assays and live-cell fluorescence imaging. One conjugation scheme that has a number of advantages is the self-asse...

Scanning probe based patterning techniques have the unique ability to deposit biological material into specific architectures on substrates and read and analyze the patterns using an atomic force microscope. Such devices are able to make much smaller biomolecule patterns, on the order of nanometers, than conventional techniques such as microcontact printing and optical lithography. A reduction ...