With the advent of very rapid and cheap genome analyses and the linkage of these plus microbial metabolomics to potential compound structures came the realization that there was an immense sea of novel agents to be mined and tested. In addition, it is now recognized that there is significant microbial involvement in many natural products isolated from "nominally non-microbial sources". This sho...

This review describes biologically active natural products displaying antitumor activities derived from fruit bodies and cultured mycelium of macromycetes. Among these compounds the most important are: polisaccharides, phenols, terpenes and others. Polysaccharides produce their antitumor effects by activating different immune responses in the host. Other compounds are examples of cytotoxic and ...

Caged compounds are biologically active molecules that have been rendered inert by the introduction of a photolabile protecting (caging) group to an important functional group. The intracellular photolysis of the caging group to reveal the active compound provides a powerful method for the intracellular release of biologically important molecules with exquisite temporal and spatial control. Thi...

The iodination of organic compounds is great importance in synthetic chemistry. It opens comprehensive approaches for the synthesis various biologically active compounds. recent advances using elemental iodine or iodides, covering last thirteen years, are objective present review.

Our group focuses on synthesising biologically active compounds for the various stages of drug development. Several of our projects are devoted to the development of basic synthetic methodology, with a special emphasis on asymmetric synthesis, while others address the synthesis of compounds of known therapeutic interest, in which emphasis is placed on the reliability, efficiency and scalability...

Objective: The genus Ferula L. includes perennial flowering plants belonging to the Apiaceae family. This genus is a rich source of biologically active phytochemicals such as sulfur-containing derivatives, coumarins, sesquiterpenes, sesquiterpene lactones, sesquiterpene coumarins, glucuronic acid, galactose, arabinose, rhamnose, and daucane esters. Over the last decade, considerable attention h...

stachys lavandulifolia vahl is an herbaceous wild plant native to iran which is traditionally used in iranian folk medicine as a mild sedative tea for reducing anxiety and for treatment of gastrointestinal disorders. our previous study on ethyl acetate extract of s. lavandulifolia proved anti-anxiolytic activity and so the present study was designed to determine chemical components of this biol...