Food, drugs, dyes, extracts, and minerals are all made up of complex elements, utilizing unidimensional chromatography to separate them is inefficient insensitive. This has sparked the invention several linked methods, each with distinct separation principles affinity for analyte interest. Multidimensional consists combination multiple techniques, great benefits at level efficiency, peak capaci...

This guideline replaces 'Guideline on similar biological medicinal products containing biotechnology-derived proteins as active substance: Non-clinical and clinical issues' Guideline on similar biological medicinal products containing biotechnology-derived proteins as active substance: non-clinical and clinical issues

The present paper describes a methodology for rapid assessment of chemical and biological degradation products of tacrine and their bioactivity for acetylcholinesterase (AChE). Analysis was achieved by utilizing liquid chromatography coupled to parallel high resolution mass spectrometry and an on-line continuous-flow AChE bioassay for biochemical detection. Key advantage of the strategy describ...

Bioactive products from snail slime of “Helix” specie have potential applications in preventing and/or treating several human diseases and in cancer diagnosis. However, the poor pharmacokinetics characteristics of these natural compounds limit their use. Nanotechnology offers promising solutions for the enhanced formulation of these molecules through the synthesis of nanosized drug del...