Direct chemical evidence has shown that the infecting bacterial virus particle is extensively broken down during the reproductive process (1,2). This finding supports the interpretation of various studies of bacteriophage reproduction by geneticists, who have postulated that the virus is broken down to smaller units shortly after infection (3-6). The disruption of the virus particle upon infect...

The determination ofthe so-called 'ethereal sulphate content' of urine is a simple analytical procedure, and there are many reports in the literature which show that the administration of phenols to experimental animals is followed by an increased excretion ofethereal sulphates in the urine. On the other hand, because of the difficulties which have usually been encountered, relatively few ether...

Despite frequent speculation concerning the mode of action of viruses, few biochemical studies of the virus-host cell relationship have been undertaken, and the sequence of steps in virus multiplication remains largely unknown. Any tenable theory of virus reproduction must consider both the r&e and the fa,te of the original infecting virus particle, and, at present, little evidence is available...

Regenerating liver of the rat has long been recognized as a source of relatively abundant quantities of homogeneous rapidly growing tissue. Following the removal of the two largest lobes of the liver, the remaining ones, constituting about one-third of the total, enlarge to the size of the original liver in the span of a few days. The work of Higgins and Anderson (l), Brues et al. (2), and othe...

The active transport process, so important in cell function, has been studied in the past with intact cells. Models which have arisen from this work all depend on: first, a specific protein to recognize the substrate; second, translocation of the substrate across the cell membrane; third, release of substrate within the cell and restoration of the system to its initial state. These steps are ad...

The alpha-keto acid dehydrogenase complex and its component enzymes, lactate dehydrogenase, pyruvate carboxylase, cytochrome c oxidase, succinate-cytochrome c reductase, NADH-cytochrome c reductase, and the concentration of cytochromes and enzymes of beta-oxidation in muscle from a patient with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes were studied and no ...

Large numbers of taste buds are distributed over the body surface of the channel catfish Zctalurus punctatus, with the barbels having an especially high density. L-Alanine, as well as certain other amino acids, are taste stimuli in this animal. Epithelial tissue obtained by gentle scraping of the barbel surface was fractionated by differential centrifugation. A sedimentable fraction (P2) was pr...

Thyroxine has been shown to accelerate the synthesis of carbamyl phosphate synthetase in the liver of Rana catesbeiana. Stimulation of carbamyl phosphate synthetase synthesis by thyroxine appears to be relatively specific because of the following observations: (1) succinoxidase activity decreased during the time that carbamyl phosphate synthetase increased; (2) liver catalase responded more slo...

In a previous paper (1) we reported the results of a study of the blood chemistry of hens bearing the Rous sarcoma No. 1. In this paper it was shown that there were no changes in the nonprotein nitrogen, uric acid, creatinine, chlorides, cholesterol, serum calcium and inorganic phosphorus, hemoglobin, and bilirubin, of the bloods of sarcoma-bearing hens when compared with the same determination...