background: the purpose of this study was to evaluate the prognostic effect of hyaluronan binding assay (hba) which has been used as a method of sperm selection for intracytoplasmic sperm injection procedure, on the outcome of intrauterine insemination (iui) in couples with unexplained or mild male factor infertility. methods: 77 infertile couples were enrolled in our study. on the day of iui p...

Apotransferrin (apo Tf)  in 0.1 M N-(2hydroxyethyl)piperazine-N2-ethanesulfanic acid at 25 ˚C  and pH 7.4 has been titrated with acidic solution of Tb3+. The binding of Tb3+ at  the two specific metal-binding sites of transferrin was followed from the changes in the difference UV spectra at 245 nm. The molar absorptivity per binding site for Tb3+...

Wnts are the major ligands responsible for activating Wnt signaling pathway through binding to Frizzled proteins (Fzd) as the receptors. Among these ligands, Wnt2 plays the main role in the tumorigenesis of several human cancers especially colorectal cancer (CRC). Therefore, it can be considered as a potential drug target.The aim of this study was to identify potential drug candidates ...

human serum albumin (hsa) is the most abundant protein in the blood plasma. drug binding to hsa is crucial to study the absorption, distribution, metabolism, efficiency and bioavailability of drug molecules. in this study, isothermal titration calorimetry and molecular dynamics simulation of hsa and its complex with indometacin (im) were performed to investigate thermodynamics parameters and th...

The Election Organizer Ethics (DKPP)’s Decision in adjudicating administrator ethical disputes is final and binding. This raises a problem, that is, if the DKPP decides an dispute deviates from legal provisions, then there no way to test it. Thus, author intends analyze comprehensively regarding, First, binding nature of results election ethics trial perspective state administrative law. Second...

conclusions the established method has an acceptable performance in quantifying yb-1. in addition, serum yb-1 may aid in the diagnosis of hcc. results the developed method was linear to 150 μg/l of yb-1 with a minimum detection limit of 0.01 μg/l. the average recoveries were between 93.9% and 109.0%. the mean intra- and inter-assay coefficients of variation (cvs) were 4.0-4.8% and 8.2-10.2%, re...

results serum estradiol levels tended to have a negative correlation with homeostasis model assessment of insulin resistance (homa-ir) in premenopausal women but not in postmenopausal women. on the other hand, free testosterone levels tended to have a positive correlation with homa-ir in postmenopausal women but not in premenopausal women. serum shbg levels showed significant negative correlati...

the removal of copper (ii), zinc (ii), and chromium (iii) from wastewater by carrot residues(cr) was investigated to evaluate cation exchange capacity. the effects of solution ph and co- ions werestudied in batch experiments. adsorption equilibria were initially rapidly established, and then decreasedmarkedly after 10 min. column experiments were carried out in a glass column filled with cr toe...

wilson disease is a metabolic disorder with an autosomal recessive genetic pattern and occurs in 1-4 of every 100000 individuals. inactivation of the atp7b gene leads to accumulation of the toxic copper to liver and brain causing hepatic and neurological complication. therefore, most patients suffer from chronic hepatic inflammation and central nervous system disorder. nowadays, up to 500 mutat...