Background: The renin-angiotensin system has an important role in hepatic inflammation and fibrosis. Renin-angiotensin system blockade by angiotensinconverting enzyme (ACE) inhibitors provides some protective effects against hepatic fibrogenesis. Captopril as an ACE inhibitor can decrease inflammatory mediators and attenuate hepatic fibrosis in the livers of bile duct ligated (BDL) rats. Object...

In laparoscopic cholecystectomy (LC), cystic duct and artery are normally secured with titanium clips. Intracorporeal ligation is normally superior to extra corporeal knotting. Most studies report of separate and multiple ligations of cystic duct and artery, which are viewed as technically demanding and time consuming. Similarly the harmonic scalpel and 'LigaSure' are prohibitory expensive for ...

liver functional tests due to inflammatory process which induced by cholecystitis might changed and some clinicians suggested that these changes might help us to stone prediction in common bile ducts and decrease hazards of performing ercp and other invasive procedures. present study was performed for assessment of role of liver functional test in diagnosis of common bile duct stone in patients...

1. Marker enzymes for the principal subcellular organelles of rat liver were asayed in the liver of rats 1 day and 8 days after bile-duct ligation or after laparotomy as a control procedure. 2. The microsomal enzymes in liver tissue showed complex changes. Benz[alpha]pyrene hydroxylase activity, predominantly found in the smooth endoplasmic reticulum, was decreased. Glucose 6-phosphatase activi...

PAPAVASILIOU, P. S., S. T. MILLER, AND G. C. COTZIAS. Role of liver in regulating distribution and excretion of manganese. Am. J. Physiol. 2 I-I (I) : -2 I 1-2 16. I g66.-Rectal obstruction abolished the total-body loss of Mns4 in both manganese-loaded and jaundiced rats. Bile duct obstruction only diminished the excretion of the radioisotope, proving that several gastrointestinal routes excret...

BACKGROUND The standard model for research in cholestasis is the total ligation of the bile duct (tBDL). Because this model causes severe hepatic injury in mice, we developed a novel model of cholestasis using a partial bile duct ligation (pBDL) and evaluate different mechanisms of injury. METHODS Male C57Bl/6 mice were subjected to sham operation, tBDL, or pBDL. Blood from tail veins was tak...

mirizzi’s syndrome is a rare complication of gallstone disease , that gallbladder lumen can lie alongside the common hepatic duct, resulting in inflamation and resultan bile duct stricture . most cases are not indentified preoperatively. variations of the cystic duct and its point of :union: with the common hepatic duct are surgically important . here, we present an unusual case of type i miriz...

Hepatic encephalopathy (HE) arises from acute or chronic liver diseases and leads to several problems, including motor impairment. Animal models of chronic liver disease have extensively investigated the mechanisms of this disease. Impairment of locomotor activity has been described in different rat models. However, these studies are controversial and the majority has primarily analyzed activit...

Possibly, acute esophagitis and pancreatitis cause each other, and we focused on sphincteric failure as the common causative key able to induce either esophagitis and acute pancreatitis or both of them, and thereby investigate the presence of a common therapy nominator. This may be an anti-ulcer pentadecapeptide BPC 157 (tested for inflammatory bowel disease, wound treatment) affecting esophagi...

PAPAVASILIOU, P. S., S. T. MILLER, AND G. C. COTZIAS. Role of liver in regulating distribution and excretion of manganese. Am. J. Physiol. 2 I-I (I) : -2 I 1-2 16. I g66.-Rectal obstruction abolished the total-body loss of Mns4 in both manganese-loaded and jaundiced rats. Bile duct obstruction only diminished the excretion of the radioisotope, proving that several gastrointestinal routes excret...