The lack of efficient neuroprotective strategies for neonatal stroke could be ascribed to pathogenic ischemic processes differentiating adults and neonates. We explored this hypothesis using a rat model of neonatal ischemia induced by permanent occlusion of the left distal middle cerebral artery combined with 50 min of occlusion of both common carotid arteries (CCA). Postconditioning was perfor...

Severe carotid stenosis or occlusion may cause insufficient blood flow and lead to distal artery wall collapse and extensive lumen contraction. Whether this 'adaptive narrowing' can restitute after carotid recanalization is unclear. We report a patient with global ischemia due to occlusions of bilateral carotid and right vertebral arteries. The occluded left carotid was recanalized successfully...

Carotid artery is the most important artery that carries the major part of the blood supply to the head and neck. The branching of the common carotid artery usually occurs at the upper edge of the thyroid cartilage. The placement of carotid sinus has also increased its importance in this area. Considering the clinical importance of knowledge about carotid artery variations, this case is reporte...

Cerebral blood flow (CBF) and the response to hypercapnia (cerebral reactivity) have been measured in 41 patients with unilateral or bilateral internal carotid artery occlusion in an attempt to identify those with limited collateral reserve. Normocapnic CBF was within normal limits in the majority of subjects. The response to hypercapnia varied from normal to absent, with impaired reactivity be...

Retinal artery pressure was measured by ophthalmodynamometry in 15 patients with occlusion of the internal carotid artery in its extracranial part. Nine of the patients had severe neurological deficit whereas the remaining six had slight or intermittent symptoms. Retinal artery pressure was reduced on the side of the internal carotid artery occlusion in all patients studied. Near-zero low diast...

In this study, cerebral blood flow, oxygenation, metabolic, and electrical functional responses to forepaw stimulation were monitored in rats at different levels of global cerebral ischemia from mild to severe. Laser speckle contrast imaging and optical imaging of intrinsic signals were used to measure changes in blood flow and oxygenation, respectively, along with a compartmental model to calc...

BACKGROUND AND PURPOSE Blood pressure lowering in patients with a previous transient ischemic attack (TIA) or stroke reduces the risk of recurrent stroke and coronary vascular events. However, there is uncertainty about the risks and benefits in patients with severe carotid occlusive disease, particularly those with a carotid occlusion or bilateral > or =70% carotid stenosis in whom cerebral pe...