نتایج جستجو برای: bet v 1

تعداد نتایج: 2931688  

Journal: :Journal of investigational allergology & clinical immunology 2009
F Pirson B Detry C Pilette

We report the case of a patient working in a factory producing inulin from chicory who developed rhinoconjunctivitis and asthma to the dust of dry chicory roots and oral allergy syndrome to raw fruits and vegetables. Nonspecific bronchial hyperresponsiveness was diagnosed. A provocation test with dry chicory induced acute rhinoconjunctivitis and an immediate asthmatic response with no further c...

2014
A. Roulias U. Pichler M. Hauser M. Himly H. Hofer P. Lackner C. Ebner P. Briza B. Bohle M. Egger M. Wallner F. Ferreira

BACKGROUND Birch pollen allergies are frequently associated with adverse reactions to various fruits, nuts, or vegetables, described as pollen-food syndrome (PFS) and caused by cross-reactive IgE antibodies primarily directed against Bet v 1. Specific immunotherapy (SIT) represents an effective treatment for inhalant allergies; however, successful birch pollen SIT does not correlate well with t...

2013
Sergey Gusenkov Chloé Ackaert Hanno Stutz

A CZE-ESI-TOF MS method has been optimized for the separation and identification of nitrated variants of the major birch pollen allergen from Betula verrucosa, isoform 1a (Bet v 1a). In-house nitration of recombinant Bet v 1a was done by peroxynitrite. As a BGE, 10 mmol/L ammonium bicarbonate with pH 7.50 provided best resolution. Nebulizer gas pressure and sheath liquid flow rate of 0.4 bar an...

2014
Stephan Deifl Christian Zwicker Eva Vejvar Claudia Kitzmüller Gabriele Gadermaier Birgit Nagl Susanne Vrtala Peter Briza Gerhard J. Zlabinger Beatrice Jahn-Schmid Fatima Ferreira Barbara Bohle Lucienne Chatenoud

BACKGROUND Recently, a protein homologous to glutathione-S-transferases (GST) was detected in prominent amounts in birch pollen by proteomic profiling. As members of the GST family are relevant allergens in mites, cockroach and fungi we investigated the allergenic relevance of GST from birch (bGST). METHODOLOGY bGST was expressed in Escherichia coli, purified and characterized by mass spectro...

2017
Heidi Hofer Claudia Asam Michael Hauser Birgit Nagl Josef Laimer Martin Himly Peter Briza Christof Ebner Roland Lang Thomas Hawranek Barbara Bohle Peter Lackner Fátima Ferreira Michael Wallner

BACKGROUND Allergy vaccines should be easily applicable, safe, and efficacious. For Bet v 1-mediated birch pollen and associated food allergies, a single wild-type allergen does not provide a complete solution. OBJECTIVE We aimed to combine immunologically relevant epitopes of Bet v 1 and the 2 clinically most important related food allergens from apple and hazelnut to a single hybrid protein...

Journal: :The Biochemical journal 2008
Hanna Berkner Kristian Schweimer Irena Matecko Paul Rösch

The enzyme NCS [(S)-norcoclaurine synthase; EC 4.2.1.78] found in the common meadow rue, Thalictrum flavum, and other plant species, is involved in the biosynthesis of BIAs (benzylisoquinoline alkaloids). This group of plant secondary metabolites comprises pharmacologically-active compounds such as morphine and codeine. NCS catalyses the condensation of 4-HPAA (4-hydroxyphenylacetaldehyde) and ...

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