In 1933 Weber and Engelhardt reported the first case of acute pneumonitis due to beryllium poisoning. Other instances of the acute reaction to beryllium salts were described by Van Ordstrand, Hughes, DeNardi, and Carmody (1945). Hardy and Tabershaw (1946) gave details of the chronic or delayed form of the disease, and DeNardi, Van Ordstrand, Curtis, and Zielinski (1953) published a review of 46...

RATIONALE Beryllium continues to have a wide range of industrial applications. Exposure to beryllium can lead to sensitization (BeS) and chronic beryllium disease (CBD). OBJECTIVES The purpose of this statement is to increase awareness and knowledge about beryllium exposure, BeS, and CBD. METHODS Evidence was identified by a search of MEDLINE. The committee then summarized the evidence, dre...

BACKGROUND In this study, we evaluated alternative possibility for CFSE beryllium flow cytometric test against beryllium blood lymphocyte proliferation test (BeLPT) as a standard radioactive clinical screening method to identify sensitization to beryllium. METHODS Delta PD (the ratio of divided cell population to the total number of cells with subtracted counts of unstimulated cells) of speci...

The beryllium lymphocyte transformation test was performed on 16 patients with chronic beryllium disease, 10 subjects (seven patients and three young boys) who were under suspicion, and 117 healthy beryllium workers. The tests gave a positive response in all patients with definite disease and a negative response in the suspected group. Two of the healthy workers had a positive response, indicat...

We present the first detection of beryllium in two turnoff stars of the old, metal-poor globular cluster NGC 6397. The beryllium lines are clearly detected and we determine a mean beryllium abundance of log(Be/H)= −12.35± 0.2. The beryllium abundance is very similar to that of field stars of similar Fe content. We interpret the beryllium abundance observed as the result of primary spallation of...

Chronic beryllium disease (CBD) begins as a sensitizing cell-mediated immune response to beryllium antigen that progresses to granulomatous lung disease. Previous studies demonstrated the involvement of proinflammatory cytokines in the disease process, but the pattern and regulation of cytokine release is unknown. Using bronchoalveolar lavage (BAL) cells from CBD patients in short-term tissue c...

OBJECTIVES Chronic beryllium disease (CBD) shares many of its characteristics with sarcoidosis and is often treated with corticosteroids. There is limited available literature regarding the effect of long-term corticosteroid therapy on the natural history of CBD. METHODS AND MATERIALS We conducted an observational retrospective study of six patients with CBD who received prolonged corticoster...

We herein investigate the interaction of beryllium with a graphene sheet and in a bilayer of graphite by means of periodic DFT calculations. In all cases, we find the beryllium atoms to be more weakly bonded on graphene than in the bilayer. Be2 forms both magnetic and non-magnetic structures on graphene depending on the geometrical configuration of adsorption. We find the stability of the Be/bi...

Epidemiological studies have reported process-specific elevated prevalence of beryllium sensitization (BeS) and chronic beryllium disease (CBD) among workers. However, exposure-response relationships have been inconsistent, possibly due to incomplete characterization of many biologically relevant aspects of exposure, including particle size. In 1999, two surveys were conducted 3-5 months apart ...

BACKGROUND Isolated cases of allergic contact dermatitis, gingivitis and stomatitis caused by beryllium have been previously reported. We have been able to study a series of 12 patients with patch test reactions to beryllium chloride. OBJECTIVES The study was aimed at defining the clinical and patch testing characteristics in this group of patients, and determining whether some were delayed e...