Granulomatous lesions of the skin produced by beryllium compounds were first described by Grier, Nash, and Freiman (1948), but no case occurring in this country has yet been published. As interest in the effects of exposure to beryllium has grown with the increased use of this metal during the last decade, a case of multiple beryllium granulomatosis of the skin occurring in a girl of 20 years i...

Beryllium is the fourth element in the periodic table and the second lightest metal known. Discovered as an oxide in 1798 by the French chemist L. N. Vauquelin, beryllium was first isolated in 1828, when it was called "glucinium" owing to the sweet taste of its salts. Beryllium is the lightest of all solid, chemically stable substances and has an unusually high melting point (12870C). Silver gr...

The human leukocyte antigen (HLA) complex is a series of genes located on chromosome 6 that are important in normal immune function. Susceptibility to chronic beryllium disease, a granulomatous lung disease that appears in workers exposed to beryllium, is modified by genetic variants of the HLA-DP subregion. Evaluation of HLA-DPB1 sequence motifs in current and former beryllium workers implicat...

Within recent years a number of reports have appeared demonstrating the toxicity of beryllium in humans and animals. Relatively little is known, however, about the mode of action of beryllium in the body. Klemperer, Miller, and Hill (l), as well as Crier, Hood, and Hoagland (2), have demonstrated an inhibitory action of beryllium on alkaline phosphatase and have suggested the possibility that t...

Chronic beryllium disease (CBD) is caused by workplace exposure to beryllium and is characterized by the accumulation of memory CD4+ T cells in the lung. These cells respond vigorously to beryllium salts in culture by producing proinflammatory Th1-type cytokines. The presence of these inflammatory cytokines leads to the recruitment of alveolar macrophages, alveolitis, and subsequent granuloma d...

We conducted a medical screening for beryllium disease of 577 former workers from a beryllium processing facility. The screening included a medical and work history questionnaire, a chest radiograph, and blood lymphocyte proliferation testing for beryllium. A task exposure and a job exposure matrix were constructed to examine the association between exposure to beryllium and the development of ...

The baseline toroidal field coil system of the FIRE tokamak utilizes inertially cooled, copper alloy Bitter plate type magnets which are LN2 cooled between shots. The TF configuration is wedged and uses C17510 high strength, high conductivity beryllium copper alloy which was developed for BPX in the inner leg, where the stress is highest. In FY 01, a slightly larger design was adopted (R=2.14 m...

The toroidal field coil system of the FIRE tokamak utilizes inertially cooled, copper alloy Bitter plate type magnets which are LN2 cooled between shots. The baseline configuration is wedged. C17510 high strength, high conductivity beryllium copper alloy developed for BPX is proposed for the conductor. These design choices were made after considering a number of alternative structural concepts ...

ABSTRCT Toxic effects of beryllium salts on the reproductive organs of cyclic adult female albino rats have been studied. An attempt was made to overcome these effects using an Ayurvedic medicine Liv.52 (The Himalaya Drug Co., Bombay). Liv.52-primed rats (1 mL/rat/day for 15 days) were exposed to beryllium nitrate intravenously and were sacrificed at different time intervals. At autopsy ovary, ...

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