In this letter a recursive and computationally efficient new formula for bit error rate (BER) in multipath channels with several specular components is derived. Using Jensen’s inequality it is shown that one specular component, Rice fading, provides the lowest possible BER. Using Lagrange multipliers to solve a constrained optimization problem, it is further shown that for two specular componen...

Base excision repair (BER) protects cells from nucleobase DNA damage. In eukaryotic BER, DNA glycosylases generate abasic sites, which are then converted to deoxyribo-5'-phosphate (dRP) and excised by a dRP lyase (dRPase) activity of DNA polymerase beta (Polbeta). Here, we demonstrate that NEIL1 and NEIL2, mammalian homologs of bacterial endonuclease VIII, excise dRP by beta-elimination with th...

This work investigates the improvement in Bit Error Rate (BER) with different antenna configuration using beamforming technique. In this paper Linearly Constrained Minimum Variance (LCMV) beamforming is used and based on this BER graph is plotted. The idea is to show improvement in BER performance with increasing number of antenna and also to show that the data rate can be increased if BER is b...

Alzheimer's disease (AD) has been correlated with elevated levels of oxidative DNA damage. Base excision repair (BER) is the main repair pathway for the removal of oxidative DNA base modifications. We have recently found significant functional deficiencies in BER in brains of sporadic AD and amnestic mild cognitive impairment patients. In this study we tested whether altered BER activities are ...

We introduce a method that allows analytical or semianalytical estimating of the post-error correction bit error rate (BER) when a forward-error correction is utilized for transmitting information through a noisy channel. The generic method that applies to a variety of error-correction schemes in the regimes where the BER is low is illustrated using the example of a finite-size code approximate...

this paper investigates the multi-band ofdm (mb-ofdm) based physical (phy) layer proposal for ieee 802.15.3a working group on short-range high data-rate ultra-wide-band (uwb) communications. an overview of the mb-ofdm phy layer architecture with its various parameters is presented and the optimal choice of critical parameters is discussed. next, we derive the theoretical un-coded bit error rate...

AIM Our previous works have demonstrated that Chinese herb medicine yanhusuo (Corydalis yanhusuo W. T. Wang) has strong anti-cancer proliferation effect in MDA-MB-231 cells. The goal of this study was to find out the synergic cytotoxicity effect of three natural compounds, tetrahydropalmatine (THP), berberine (Ber), and dehydrocorydaline (DHC), isolated from C. yanhusuo W. T. Wang. MATERIALS ...

Base excision repair (BER) plays a critical role in the repair of bases damaged by oxidative metabolism or alkylating agents, such as those commonly used in cancer therapy. Incomplete BER generates intermediates that require activation of homology-dependent DNA repair to resolve. We investigated the effects of lithocholic acid (LCA), an inhibitor of the key BER enzyme DNA polymerase beta (pol b...

UNLABELLED PARP-1 is important for the recognition of both endogenous and exogenous DNA damage, and binds to DNA strand breaks including intermediates of base excision repair (BER). Once DNA-bound, PARP-1 becomes catalytically activated synthesizing PAR polymers onto itself and other repair factors (PARylation). As a result, BER repair proteins such as XRCC1 and DNA polymerase β (pol β) are mor...

Base excision repair (BER) provides relief from many DNA lesions. While BER enzymes have been characterized biochemically, BER functions within cells are much less understood, in part because replication bypass and double-strand break (DSB) repair can also impact resistance to base damage. To investigate BER in vivo, we examined the repair of methyl methanesulfonate (MMS) induced DNA damage in ...