The title compound, C(14)H(8)F(2)O(2), is a substituted benzil with an s-trans conformation of the dicarbonyl unit. This conformation is also shown by the O-C-C-O torsion angle of -110.65 (12)°. An unusual feature of the structure is the length, 1.536 (2) Å, of the central C-C bond connecting the carbonyl units, which is significantly longer than a normal Csp(2)-Csp(2) single bond. This is prob...

The spontaneous and collision-assisted hydrogen-atom abstracting reaction (HA) dynamics of triplet benzil are investigated through the combination of transient absorption spectroscopy with TD-DFT calculations. HA dynamics exhibit a remarkable dependence on the hydrogen donor properties. The effects of the triplet-state hydrogen bonding on the reaction dynamics are illustrated. In particular, it...

Two morphine prodrugs ('PDA' and 'PDB') were synthesized and the kinetics of esterase-mediated morphine release from these prodrugs were determined when incubated with plasma from different animal species. Morphine was rapidly released from PDA by all species plasma with the maximum reached within 5-10min; the released morphine was biologically active as determined by an in vitro cAMP assay. Th...

Prof Angeli recently discovered another synthesis of the same compound and was kind enough to inform me by letter[2] and allow their use at this point: benzilic acid condenses after merging with symmetrical dimethylurea to lose two water molecules and gives the same expected products (shown to me and sent in a sample). Crystal form, melting point and mixed melting point were identical. From the...

New, simple and cost effective spectrophotometric methods have been developed for the quality assessment of isoniazid (INH), in bulk and in pharmaceutical formulations by using novel reagents. The proposed methods involve the utility of ethyl 2-[(E)-(4hydroxyphenyl) diazenyl]-3-oxobutanoate and benzil as novel reagents for the determination of INH. Developed methods are based on the condensatio...

The photophysics of 2,2'-pyridil has been explored thoroughly using steady state and time resolved fluorometric techniques at room temperature (RT) in liquid media as well as in glassy matrices at cryogenic temperature (77 K). Ethanol and methylcyclohexane are exploited for this purpose, as polar and non-polar media respectively. Notwithstanding the observation of multiple emissions from the fl...

The present paper describes studies on the synthesis of the antiepileptic drug phenytoin, and of structurally related derivatives. First, the influence of the solvent has been investigated in the microwave-assisted synthesis of the drug, resulting in a yield improvement and a cleaner reaction. Second, a two-step reaction is described to synthesize selectively and in high yields phenytoin. The f...