A series of Schiff’s bases i.e., N-(4-(benzylideneamino)-2-phenoxyphenyl)-4-methylbenzene-sulfonamide were synthesized from Nimesulide and studied for their in vivo anti-inflammatory activity. Hydrolysis of Nimesulide with sulphuric acid led to the formation 1 which on further reaction with benzene sulphonyl chloride yielded the title compounds 2. Compounds 2 reduced with tin in presence of con...

Unprotected tertiary sulfonimidamides have been prepared in good to excellent yields in a one-pot transformation from tertiary sulfinamides through NH transfer. The reaction is mediated by commercially available (diacetoxyiodo)benzene and ammonium carbamate in methanol under convenient conditions. A wide range of functional groups are tolerated and initial results indicate that the NH transfer ...

In the title compound, K(+)·C(6)H(4)Cl(2)NO(2)S(-)·1.5H(2)O, one water mol-ecule has crystallographically imposed twofold symmetry. The K(+) ion is heptacoordinated by three O atoms from water mol-ecules and by four sulfonyl O atoms of N-chloro-2-chloro-benzene-sulfonamide anions. The S-N distance of 1.582 (2) Å is consistent with an S-N double bond. In the structure, the sulfonyl-O and the wat...

The title Schiff base compound, C(13)H(11)N(3)O(5)S, exists in an E configuration with respect to the C=N double bond. The benzene rings are almost coplanar, making a dihedral angle of 2.82 (6). The sulfonamide group is twisted away from the attached phenyl ring with an N-S-C-C torsion angle of 64.84 (11)°. An intra-molecular O-H⋯N hydrogen bond stabilizes the mol-ecule, generating an S(6) ring...

The title compound, 0.61C(19)H(17)BrN(4)O(3)S·0.39C(19)H(17)BrN(4)O(3)S, is a Schiff base derived from 5-bromo-salicylaldehyde and 4-amino-N-(4,6-dimethyl-2-pyrimidin-yl)benzene-sulfonamide(sulfamethazine) and is isostructural with its chloro analogue. The geometry of the title mol-ecule points to the enol (OH-C=C-C=N) form as the major tautomer, however two electron-density maxima correspondin...

A novel protocol using H-point standard addition method (HPSAM) has been developed for simultaneous determination of cobalt and iron metals. We have herein focused on measurement concentration an analyte (cobalt) in the presence other serving as interfering species (iron). 4-[3-hydroxy-3-(4-methylphenyl) triaz-1-ene-1-yl] benzene sulfonamide (HTSN) was employed reagent Triton x-100 which served...

BACKGROUND Quinoline derivatives have diverse biological activities including anticancer activity. On the other hand, many sulfonamide derivatives exhibited good cytotoxic activity. Hybrids of both moieties may present novel anticancer agents. RESULTS Chloroquinoline incorporating a biologically active benzene-sulfonamide moieties 5-21 and diarylsulfone derivatives 22 and 23 were prepared usi...

BACKGROUND The safety of sulfonamide nonantibiotics is unclear in patients with prior allergic reactions to sulfonamide antibiotics. METHODS We conducted a retrospective cohort study using the General Practice Research Database in the United Kingdom, examining the risk of allergic reactions within 30 days after the receipt of a sulfonamide nonantibiotic. Patients with evidence of prior hypers...

several cycline dependent kinase 2 (cdk2) inhibitors with different chemical structures have been introduced. the hinge region of cdk2 (residues 81–84) contains a set of hydrogen bond donor and acceptor sites some of which must be satisfied for potent inhibitor binding. the benzimidazolone skeleton may provide such interactions. accordingly, 3-sulfonamide substituted benzamido-benzimidazolones ...