نتایج جستجو برای: behavioral sensitization

تعداد نتایج: 164721  

Journal: :Pharmacology, biochemistry, and behavior 2003
Anne-Sophie Villégier Gérard Blanc Jacques Glowinski Jean-Pol Tassin

Drugs of abuse, such as D-amphetamine or nicotine, are generally considered as acting through an increased release of dopamine in a subcortical structure, the nucleus accumbens, thus inducing locomotor hyperactivity in rats. Following repeated treatments, the same drugs induce a progressive increase in locomotor response called behavioral sensitization. This process has been suggested to play a...

Journal: :Experimental and clinical psychopharmacology 2014
Kristen R Hamilton Brenda M Elliott Sarah Shafer Berger Neil E Grunberg

Environmental enrichment decreases nicotine reactivity in male rats, but these effects have not been examined in females. This research was conducted to examine the effects of enrichment on nicotine behavioral sensitization (i.e., nicotine reactivity) in male and female rats. One hundred forty-four Sprague-Dawley rats (72 male, 72 female) were raised in isolation, social enrichment (groups of t...

Journal: :Behavioural brain research 1988
D M Camp T E Robinson

Repeated amphetamine use produces an enduring sensitization of brain dopamine (DA) systems and behavior. Repeated exposure to stress can also produce sensitization, and amphetamine and stress may be interchangeable in this regard. There is, however, enormous individual variation in the susceptibility to sensitization by either stimulants or stress. The purpose of the present study was to determ...

Journal: :Environmental Health Perspectives 1997
B A Sorg B M Prasad

Chemical sensitivity in humans may be an acquired disorder in which individuals become increasingly sensitive to chemicals in the environment. It is hypothesized that in individuals with multiple chemical sensitivity (MCS), a sensitization process has occurred that is akin to behavioral sensitization and kindling observed in rodents. In the rodent sensitization model, repeated exposure to stres...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2003
Ming Hu Jill B Becker

Estrogen rapidly enhances dopamine (DA) activity in the striatum and nucleus accumbens as well as behavioral responses to psychomotor stimulants in female rats but not males. This experiment was conducted to investigate the role of pulsatile estrogen treatment on and sex differences in the development and expression of sensitization of cocaine-induced rotational behavior in rats with unilateral...

Journal: :Drug and alcohol dependence 2013
Andrew L Eagle Shane A Perrine

BACKGROUND Single prolonged stress (SPS) is a rodent model of posttraumatic stress disorder (PTSD)-like characteristics. Given that PTSD is frequently comorbid with substance abuse and dependence, including methamphetamine (METH), the current study sought to investigate the effects of SPS on METH-induced behavioral sensitization. METHODS In experiment 1, Sprague-Dawley rats were subject to SP...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 1999
D F Fiorino A G Phillips

Behavioral sensitization caused by repeated and intermittent administration of psychostimulants, such as cocaine and D-amphetamine, is accompanied by enhanced function in limbic-motor circuitry that is involved in the generation of motivated behavior. The present microdialysis study investigated the effect of D-amphetamine-induced sensitization on dopamine (DA) efflux in the nucleus accumbens (...

Journal: :Science 1988
K P Scholz J H Byrne

Intracellular signals that trigger long-term (24-hour) changes in membrane currents in identified neurons of Aplysia have been examined in order to understand the cellular mechanisms underlying long-term sensitization. Adenosine 3',5'-monophosphate (cAMP) was directly injected into individual sensory neurons to mimic the effects of sensitization training at the single cell level. Potassium curr...

Journal: :Pharmacology, biochemistry, and behavior 1987
T E Robinson D M Camp

The repeated intermittent administration of relatively low doses of amphetamine (AMPH) produces an enduring hypersensitivity to the motor stimulant effects of AMPH (behavioral sensitization), and this is accompanied by enhanced mesotelencephalic dopamine (DA) utilization/release. In contrast, chronic treatment with very high doses of AMPH does not produce sensitization, but is neurotoxic, resul...

Journal: :Current Biology 2014
Robyn J. Crook Katharine Dickson Roger T. Hanlon Edgar T. Walters

Sublethal injury triggers long-lasting sensitization of defensive responses in most species examined, suggesting the involvement of powerful evolutionary selection pressures [1]. In humans, this persistent nociceptive sensitization is often accompanied by heightened sensations of pain and anxiety [2]. While experimental [3] and clinical [4] evidence support the adaptive value of immediate nocic...

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